From: N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition
IVSd | LVPWd | LVIDd | LVIDs | LVEF | LVFS | IVRT | EDT | EAT | |
---|---|---|---|---|---|---|---|---|---|
(mm) | (mm) | (mm) | (mm) | (%) | (%) | (ms) | (ms) | (ms) | |
Control | 0.72 ± 0.04 | 0.70 ± 0.01 | 3.42 ± 0.31 | 1.98 ± 0.28 | 81.08 ± 4.6 | 42.31 ± 3.8 | 11.56 ± 1.74 | 11.00 ± 0.71 | 33.06 ± 3.27 |
NAC only | 0.66 ± 0.05 | 0.67 ± 0.04 | 3.48 ± 0.08 | 2.06 ± 0.09 | 79.72 ± 2.58 | 40.80 ± 1.48 | 11.08 ± 0.66 | 11.80 ± 0.97 | 34.06 ± 2.48 |
NAC1 | 0.66 ± 0.05△ | 0.65 ± 0.05△ | 3.44 ± 0.05△ | 2.00 ± 0.70△ | 80.79 ± 2.3△ | 41.86 ± 1.6△ | 14.86 ± 0.78*△ | 13.86 ± 1.49*△ | 33.84 ± 2.67△ |
NAC3 | 0.66 ± 0.05△ | 0.65 ± 0.05△ | 3.62 ± 0.04△ | 2.12 ± 0.13△ | 79.80 ± 3.1△ | 41.45 ± 3.1△ | 15.00 ± 0.71*△ | 14.60 ± 0.89*△ | 34.24 ± 3.74△ |
NAC5 | 0.64 ± 0.05*△ | 0.59 ± 0.02* | 3.92 ± 0.17*△ | 2.44 ± 0.15*△ | 75.89 ± 1.4*△ | 37.78 ± 1.2*△ | 18.14 ± 1.33*△ | 17.14 ± 2.02*△ | 35.56 ± 3.56△ |
NAC7 | 0.62 ± 0.04*△ | 0.56 ± 0.04* | 4.10 ± 0.25*△ | 2.84 ± 0.21*△ | 66.69 ± 3.1*△ | 30.74 ± 2.2*△ | 20.74 ± 1.02* | 20.38 ± 1.07* | 37.18 ± 2.84 |
DM | 0.52 ± 0.07* | 0.53 ± 0.07* | 4.76 ± 0.28* | 3.58 ± 0.24* | 57.21 ± 5.3* | 24.75 ± 3.2* | 21.08 ± 0.99* | 21.22 ± 3.14* | 48.60 ± 2.30* |
p valuea | 0.585 | 0.008 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | 0.384 |