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Table 2 Comparison of echocardiographic morphological, systolic and diastolic functional indices

From: N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition

  IVSd LVPWd LVIDd LVIDs LVEF LVFS IVRT EDT EAT
(mm) (mm) (mm) (mm) (%) (%) (ms) (ms) (ms)
Control 0.72 ± 0.04 0.70 ± 0.01 3.42 ± 0.31 1.98 ± 0.28 81.08 ± 4.6 42.31 ± 3.8 11.56 ± 1.74 11.00 ± 0.71 33.06 ± 3.27
NAC only 0.66 ± 0.05 0.67 ± 0.04 3.48 ± 0.08 2.06 ± 0.09 79.72 ± 2.58 40.80 ± 1.48 11.08 ± 0.66 11.80 ± 0.97 34.06 ± 2.48
NAC1 0.66 ± 0.05 0.65 ± 0.05 3.44 ± 0.05 2.00 ± 0.70 80.79 ± 2.3 41.86 ± 1.6 14.86 ± 0.78* 13.86 ± 1.49* 33.84 ± 2.67
NAC3 0.66 ± 0.05 0.65 ± 0.05 3.62 ± 0.04 2.12 ± 0.13 79.80 ± 3.1 41.45 ± 3.1 15.00 ± 0.71* 14.60 ± 0.89* 34.24 ± 3.74
NAC5 0.64 ± 0.05* 0.59 ± 0.02* 3.92 ± 0.17* 2.44 ± 0.15* 75.89 ± 1.4* 37.78 ± 1.2* 18.14 ± 1.33* 17.14 ± 2.02* 35.56 ± 3.56
NAC7 0.62 ± 0.04* 0.56 ± 0.04* 4.10 ± 0.25* 2.84 ± 0.21* 66.69 ± 3.1* 30.74 ± 2.2* 20.74 ± 1.02* 20.38 ± 1.07* 37.18 ± 2.84
DM 0.52 ± 0.07* 0.53 ± 0.07* 4.76 ± 0.28* 3.58 ± 0.24* 57.21 ± 5.3* 24.75 ± 3.2* 21.08 ± 0.99* 21.22 ± 3.14* 48.60 ± 2.30*
p valuea 0.585 0.008 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 0.384
  1. Notes: No significant differences were found between control and NAC only group; *Compared with control, p < 0.05; NAC treatment groups compared with DM group, p < 0.05;a, ANOVA test among the NAC1, NAC3, NAC5 and NAC7 four groups; IVSd and LVEPWd, interventricular septal thickness and left ventricular posterior wall thickness during diastole; LVIDd and LVIDs, left ventricular internal diameter during diastole and systole; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; IVRT, isovolumic relaxation time; EDT, descending time of the transmitral Doppler E wave; EAT ,acceleration time of the transmitral Doppler E wave