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Table 2 Comparison of echocardiographic morphological, systolic and diastolic functional indices

From: N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition

 

IVSd

LVPWd

LVIDd

LVIDs

LVEF

LVFS

IVRT

EDT

EAT

(mm)

(mm)

(mm)

(mm)

(%)

(%)

(ms)

(ms)

(ms)

Control

0.72 ± 0.04

0.70 ± 0.01

3.42 ± 0.31

1.98 ± 0.28

81.08 ± 4.6

42.31 ± 3.8

11.56 ± 1.74

11.00 ± 0.71

33.06 ± 3.27

NAC only

0.66 ± 0.05

0.67 ± 0.04

3.48 ± 0.08

2.06 ± 0.09

79.72 ± 2.58

40.80 ± 1.48

11.08 ± 0.66

11.80 ± 0.97

34.06 ± 2.48

NAC1

0.66 ± 0.05

0.65 ± 0.05

3.44 ± 0.05

2.00 ± 0.70

80.79 ± 2.3

41.86 ± 1.6

14.86 ± 0.78*

13.86 ± 1.49*

33.84 ± 2.67

NAC3

0.66 ± 0.05

0.65 ± 0.05

3.62 ± 0.04

2.12 ± 0.13

79.80 ± 3.1

41.45 ± 3.1

15.00 ± 0.71*

14.60 ± 0.89*

34.24 ± 3.74

NAC5

0.64 ± 0.05*

0.59 ± 0.02*

3.92 ± 0.17*

2.44 ± 0.15*

75.89 ± 1.4*

37.78 ± 1.2*

18.14 ± 1.33*

17.14 ± 2.02*

35.56 ± 3.56

NAC7

0.62 ± 0.04*

0.56 ± 0.04*

4.10 ± 0.25*

2.84 ± 0.21*

66.69 ± 3.1*

30.74 ± 2.2*

20.74 ± 1.02*

20.38 ± 1.07*

37.18 ± 2.84

DM

0.52 ± 0.07*

0.53 ± 0.07*

4.76 ± 0.28*

3.58 ± 0.24*

57.21 ± 5.3*

24.75 ± 3.2*

21.08 ± 0.99*

21.22 ± 3.14*

48.60 ± 2.30*

p valuea

0.585

0.008

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

<0.0001

0.384

  1. Notes: No significant differences were found between control and NAC only group; *Compared with control, p < 0.05; NAC treatment groups compared with DM group, p < 0.05;a, ANOVA test among the NAC1, NAC3, NAC5 and NAC7 four groups; IVSd and LVEPWd, interventricular septal thickness and left ventricular posterior wall thickness during diastole; LVIDd and LVIDs, left ventricular internal diameter during diastole and systole; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; IVRT, isovolumic relaxation time; EDT, descending time of the transmitral Doppler E wave; EAT ,acceleration time of the transmitral Doppler E wave