Correlation of single nucleotide polymorphisms in the pregnancy-associated plasma protein-A gene with carotid plaques

Table 3 Risk of carotid plaque under different models of PAPP-A SNPs

SNPs analyzing Model^‡	Crude OR (95 % CI) ¹	P value¹	Adjusted OR (95 % CI)^§	P value^§
rs7020782
Dominant	2.33 (1.79-3.05)	<0.001	2.60 (1.93-3.48)	<0.001
Recessive	2.28 (1.41-3.66)	0.001	2.36 (1.42-3.92)	0.001
Additive	3.20 (1.95-5.24)^†	<0.001	3.48 (2.05-5.92)^†	<0.001

¹ Un-adjusted logistic regression model; OR, odds ratio
^§Adjusted for age, sex, systolic blood pressure, diastolic blood pressure, high density lipoprotein cholesterol
^‡In analyses, a additive effect of the variant (V) allele was assumed, the genotype wild (W) W/W,W/V and V/V were coded as 1,2, and 3, respectively; when a dominant effect was assumed, genotype W/W was coded as 2, and an W/V and V/V combined were coded as 1. Accordingly, scores of 2 for W/W, W/V combined and of 1 for V/V were used in the assumed recessive effect
^†Referred to AC vs. AA; CC vs. AA was not significant in additive model in logistic regression

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