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Table 3 Risk of carotid plaque under different models of PAPP-A SNPs

From: Correlation of single nucleotide polymorphisms in the pregnancy-associated plasma protein-A gene with carotid plaques

SNPs analyzing Model Crude OR (95 % CI) 1 P value1 Adjusted OR (95 % CI)§ P value§
Dominant 2.33 (1.79-3.05) <0.001 2.60 (1.93-3.48) <0.001
Recessive 2.28 (1.41-3.66) 0.001 2.36 (1.42-3.92) 0.001
Additive 3.20 (1.95-5.24) <0.001 3.48 (2.05-5.92) <0.001
  1. 1 Un-adjusted logistic regression model; OR, odds ratio
  2. §Adjusted for age, sex, systolic blood pressure, diastolic blood pressure, high density lipoprotein cholesterol
  3. In analyses, a additive effect of the variant (V) allele was assumed, the genotype wild (W) W/W,W/V and V/V were coded as 1,2, and 3, respectively; when a dominant effect was assumed, genotype W/W was coded as 2, and an W/V and V/V combined were coded as 1. Accordingly, scores of 2 for W/W, W/V combined and of 1 for V/V were used in the assumed recessive effect
  4. Referred to AC vs. AA; CC vs. AA was not significant in additive model in logistic regression