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Table 2 Association study of four SNPs in PAPP-A under different models in two groups

From: Correlation of single nucleotide polymorphisms in the pregnancy-associated plasma protein-A gene with carotid plaques

 

Carotid plaque

Controls

 

Analyzing Model: SNPs

n1

Frequency (%)

n1

Frequency (%)

P value §

rs3747823

     

Additive: GG/AG/AA

263/126/18

64.6/31.0/4.4

298/155/27

62.1/32.3/5.6

NS

Dominant: (AA + AG)/GG

144/263

35.4/64.6

182/298

38.0/62.0

NS

Recessive: AA/(AG + GG)

18/389

4.4/95.6

27/453

5.6/94.4

NS

rs7020782

     

Additive: AA/AC/CC

166/190/51

40.8/46.7/12.5

302/159/29

61.6/32.4/6.0

<0.001

Dominant: (AC + CC)/AA

241/166

59.2/40.8

188/302

38.4/61.6

<0.001

recessive: CC/(AC + AA)

51/356

12.5/87.5

29/461

5.9/94.1

0.001

rs13290387

     

Additive: GG/CG/CC

207/163/31

51.6/40.6/7.7

269/179/35

55.7/37.1/7.2

NS

Dominant: (CG + CC)/GG

194/207

48.4/51.6

214/269

44.3/55.7

NS

Recessive: CC/(CG + GG)

31/370

7.7/92.3

35/448

7.2/92.8

NS

  1. §P-values were calculated by Pearson Chi-Squared test. NS, no significance
  2. 1The number did not add up to 408 or 493, because the SNPs genotyping with LDR method had the absent value inevitably