Table 1 Transition probabilities between NYHA functional classes [13]
Transition probabilities in cycle 1 | ||||
|---|---|---|---|---|
| Â | NYHA I | NYHA II | NYHA III | NYHA IV |
Optimal medical treatment arm | ||||
NYHA Class III | 0.00 | 0.17 | 0.75 | 0.08 |
PMVR arm | ||||
NYHA Class III | 0.10 | 0.73 | 0.13 | 0.03 |
Transition probabilities in cycles 2–11 | ||||
| Â | NYHA I | NYHA II | NYHA III | NYHA IV |
Optimal medical treatment arm | ||||
NYHA Class I | 0.00 | 0.00 | 0.00 | 0.00 |
NYHA Class II | 0.00 | 0.67 | 0.00 | 0.33 |
NYHA Class III | 0.00 | 0.17 | 0.83 | 0.00 |
NYHA Class IV | 0.00 | 0.00 | 0.17 | 0.83 |
PMVR arm | ||||
NYHA Class I | 0.25 | 0.75 | 0.00 | 0.00 |
NYHA Class II | 0.11 | 0.63 | 0.26 | 0.00 |
NYHA Class III | 0.00 | 0.50 | 0.50 | 0.00 |
NYHA Class IV | 0.00 | 0.00 | 0.50 | 0.50 |
Transition probabilities in cycle 12 and onwards | ||||
| Â | NYHA I | NYHA II | NYHA III | NYHA IV |
Optimal medical treatment arm | ||||
NYHA Class I | 0.00 | 0.00 | 0.00 | 0.00 |
NYHA Class II | 0.00 | 0.50 | 0.50 | 0.00 |
NYHA Class III | 0.00 | 0.67 | 0.33 | 0.00 |
NYHA Class IV | 0.00 | 0.00 | 0.67 | 0.33 |
PMVR arm | ||||
NYHA Class I | 0.67 | 0.33 | 0.00 | 0.00 |
NYHA Class II | 0.12 | 0.71 | 0.18 | 0.00 |
NYHA Class III | 0.00 | 0.40 | 0.60 | 0.00 |
NYHA Class IV | 0.00 | 0.00 | 0.40 | 0.60 |