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Table 3 Coefficients, standard error of coefficients and p-values for the joint model predicting death and aortic valve intervention

From: Dynamic prediction of outcome for patients with severe aortic stenosis: application of joint models for longitudinal and time-to-event data

 

Coef

Exp(coef):HR

Se(coef)

p-value

Death

    

BNP at specific time point (pg/ml)

0.5

1.65

0.3

0.0962

AVA (cm2)

−2.61

0.07

1.5

0.0815

Age (years)

0.02

1.02

0.04

0.5674

Male gender

1.12

3.06

0.6

0.0623

Symptoms

1.87

6.49

1.05

0.0753

*LV ejection fraction (%)

0.01

1.01

0.25

0.9539

*Creatinine (micromol/L)

0.18

1.2

0.15

0.2162

Aortic valve intervention

    

BNP at specific time point (pg/ml)

0.18

1.2

0.25

0.4787

AVA (cm2)

−1.12

0.33

1.04

0.2804

Age (years)

−0.04

0.96

0.02

0.0077

Male gender

0.39

1.48

0.49

0.4287

Symptoms

1.08

2.94

0.46

0.0183

*LV ejection fraction (%)

0.24

1.27

0.21

0.2388

*Creatinine (micromol/L)

−1.43

0.24

1.31

0.2761

  1. BNP = brain natriuretic peptide; AVA = aortic valve area; LV = left ventricular; HR = hazard ratio. * Trasnformed LV ejection fraction and Creatinine in the models