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Table 3 Association of genotype and allele distribution of examined polymorphisms with CAD patients with poor and good CCC

From: Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization

Gene

dbSNP ID

Patients

n

Genotype count (frequency)

P valuea

Allele count (frequency)

P valueb

HWE P

VEGFA

rs2010963

  

GG

GC

CC

 

G

C

  

Poor CCC

531

247 (46.52)

224 (42.18)

60 (11.30)

0.5760

718 (67.61)

344 (32.39)

0.495

0.8216

Good CCC

121

50 (41.32)

58 (47.93)

13 (10.75)

158 (65.29)

84 (34.71)

rs1570360

  

GG

GA

AA

 

G

A

  

Poor CCC

451

207 (45.90)

197 (43.68)

47 (10.42)

0.782

611 (67.74)

291 (32.26)

0.521

0.8494

Good CCC

97

47 (48.45)

42 (43.30)

8 (8.25)

136 (70.10)

58 (29.90)

rs699947

  

CC

AC

AA

 

C

A

  

Poor CCC

494

138 (27.94)

245 (49.59)

111 (22.47)

0.816

521 (52.73)

467 (47.27)

0.968

0.5199

Good CCC

104

31 (29.81)

48 (46.15)

25 (24.04)

110 (52.90)

98 (47.12)

rs3025039

  

CC

CT

TT

 

C

T

  

Poor CCC

498

386 (77.51)

106 (21.29)

6 (1.20)

0.665

878 (88.15)

118 (11.85)

0.714

0.9533

Good CCC

105

84 (80)

19 (18.10)

2 (1.90)

187 (89.05)

23 (10.95)

rs833061

  

CC

CT

TT

 

C

T

  

Poor CCC

526

124 (23.57)

268 (50.95)

134 (25.48)

0.471

516 (49.05)

536 (50.95)

0.232

0.6392

Good CCC

121

33 (27.27)

63 (52.07)

25 (20.66)

129 (53.31)

113 (46.69)

KDR

rs1870377

  

TT

AT

AA

 

T

A

  

Poor CCC

496

291 (58.67)

178 (35.89)

27 (5.44)

0.613

760 (76.61)

232 (23.39)

0.328

0.8991

Good CCC

106

67 (63.21)

35 (33.02)

4 (3.77)

169 (79.72)

43 (20.28)

rs2305948

  

CC

CT

TT

 

C

T

  

Poor CCC

582

487 (83.68)

88 (15.12)

7 (1.20)

0.199

1062 (91.24)

102 (8.76)

0.207

0.3210

Good CCC

153

120 (78.43)

32 (20.92)

1 (0.65)

272 (88.89)

34 (11.11)

rs2071559

  

TT

CT

CC

 

T

C

  

Poor CCC

544

147 (27.02)

276 (50.74)

121 (22.24)

0.319

570 (52.39)

518 (47.61)

0.140

0.8355

Good CCC

129

29 (22.48)

64 (49.61)

36 (27.91)

122 (47.29)

136 (52.71)

CCL2

rs1024611

  

AA

AG

GG

 

A

G

  

Poor CCC

576

332 (57.64)

210 (36.46)

34 (5.90)

0.221

874 (75.87)

278 (24.13)

0.826

0.3186

Good CCC

153

94 (61.44)

46 (30.06)

13 (8.50)

234 (76.47)

72 (23.53)

rs1024610

  

AA

AT

TT

 

A

T

  

Poor CCC

516

312 (60.47)

180 (34.88)

24 (4.65)

0.516

804 (77.91)

228 (22.09)

0.715

0.6077

Good CCC

112

68 (60.71)

36 (32.15)

8 (7.14)

172 (76.79)

52 (23.21)

rs2857657

  

CC

CG

GG

 

C

G

  

Poor CCC

511

309 (60.47)

181 (35.42)

21 (4.11)

0.365

799 (78.18)

223 (21.82)

0.832

0.8093

Good CCC

111

71 (63.96)

33 (29.73)

7 (6.31)

175 (78.83)

47 (21.17)

rs2857654

  

CC

AC

AA

 

C

A

  

Poor CCC

580

336 (57.93)

211 (36.38)

33 (5.69)

0.248

883 (76.12)

277 (23.88)

0.993

0.4284

Good CCC

153

93 (60.78)

47 (30.72)

13 (8.50)

233 (76.14)

73 (23.86)

NOS3

rs1799983

  

GG

GT

TT

 

G

T

  

Poor CCC

513

211 (41.13)

216 (42.11)

86 (16.76)

0.596

638 (62.18)

388 (37.82)

0.686

0.0157*

Good CCC

110

46 (41.82)

48 (43.64)

16 (14.54)

140 (63.64)

80 (36.36)

ICAM1

rs5498

  

AA

AG

GG

 

A

G

  

Poor CCC

516

136 (26.36)

246 (47.67)

134 (25.97)

0.308

518 (50.19)

514 (49.81)

0.958

0.1039

Good CCC

112

33 (29.46)

46 (41.08)

33 (29.46)

112 (50.00)

112 (50.00)

rs3093030

  

CC

CT

TT

 

C

T

  

Poor CCC

517

134 (25.92)

248 (47.97)

135 (26.11)

0.415

516 (49.90)

518 (50.10)

0.883

0.1535

Good CCC

112

33 (29.46)

47 (41.97)

32 (28.57)

113 (50.45)

111 (49.55)

TGFB1

rs1800469

  

GG

GA

AA

 

G

A

  

Poor CCC

483

198 (50.00)

228 (47.20)

57 (11.80)

0.696

624 (64.60)

342 (35.40)

0.979

0.8844

Good CCC

100

43 (43.00)

43 (43.00)

14 (14.00)

129 (64.50)

71 (35.50)

CD53

rs6679497

  

GG

GA

AA

 

G

A

  

Poor CCC

483

198 (41.00)

228 (47.20)

57 (11.80)

0.826

624 (64.60)

342 (35.40)

0.572

0.6712

Good CCC

100

43 (43.00)

43 (43.00)

14 (14.00)

129 (64.50)

71 (35.50)

POSTN

rs3829365

  

GG

GC

CC

 

G

C

  

Poor CCC

405

357 (88.15)

22 (5.43)

26 (6.42)

0.795

736 (90.86)

74 (9.14)

0.535

0.0000*

Good CCC

76

69 (90.79)

3 (3.95)

4 (5.26)

141 (92.76)

11 (7.24)

rs1028728

  

AA

AT

TT

 

A

T

  

Poor CCC

389

242 (62.21)

128 (32.91)

19 (4.88)

0.230

612 (78.66)

166 (21.34)

0.105

0.7373

Good CCC

77

54 (70.13)

22 (28.57)

1 (1.30)

130 (84.42)

24 (15.58)

LGALS2

rs7291467

  

AA

AG

GG

 

A

G

  

Poor CCC

581

160 (27.54)

292 (50.26)

129 (22.20)

0.106

612 (52.67)

550 (47.33)

0.080

0.9589

Good CCC

151

37 (24.50)

68 (45.03)

46 (30.47)

142 (47.02)

160 (52.98)

HIF1A

rs11549465

  

CC

CT

TT

 

C

T

  

Poor CCC

518

402 (77.60)

111 (21.43)

5 (0.97)

0.563

915 (88.32)

121 (11.68)

0.474

0.4122

Good CCC

112

84 (75)

26 (23.21)

2 (1.79)

194 (86.61)

30 (13.39)

rs2057482

  

CC

CT

TT

 

C

T

  

Poor CCC

497

339 (68.21)

148 (29.78)

10 (2.01)

0.490

826 (83.10)

168 (16.90)

0.328

0.1151

Good CCC

111

70 (63.06)

38 (34.24)

3 (2.70)

178 (80.18)

44 (19.82)

  1. aFisher’s exact test was used to evaluate differences between genotype groups. bPearson’s chi-squared, χ2, was used for to evaluate the allele distribution. *p <0.05 was considered as statistically significant