Gene | dbSNP ID | Patients | n | Genotype count (frequency) | P valuea | Allele count (frequency) | P valueb | HWE P | |||
---|---|---|---|---|---|---|---|---|---|---|---|
VEGFA | rs2010963 | Â | Â | GG | GC | CC | Â | G | C | Â | Â |
Poor CCC | 531 | 247 (46.52) | 224 (42.18) | 60 (11.30) | 0.5760 | 718 (67.61) | 344 (32.39) | 0.495 | 0.8216 | ||
Good CCC | 121 | 50 (41.32) | 58 (47.93) | 13 (10.75) | 158 (65.29) | 84 (34.71) | |||||
rs1570360 | Â | Â | GG | GA | AA | Â | G | A | Â | Â | |
Poor CCC | 451 | 207 (45.90) | 197 (43.68) | 47 (10.42) | 0.782 | 611 (67.74) | 291 (32.26) | 0.521 | 0.8494 | ||
Good CCC | 97 | 47 (48.45) | 42 (43.30) | 8 (8.25) | 136 (70.10) | 58 (29.90) | |||||
rs699947 | Â | Â | CC | AC | AA | Â | C | A | Â | Â | |
Poor CCC | 494 | 138 (27.94) | 245 (49.59) | 111 (22.47) | 0.816 | 521 (52.73) | 467 (47.27) | 0.968 | 0.5199 | ||
Good CCC | 104 | 31 (29.81) | 48 (46.15) | 25 (24.04) | 110 (52.90) | 98 (47.12) | |||||
rs3025039 | Â | Â | CC | CT | TT | Â | C | T | Â | Â | |
Poor CCC | 498 | 386 (77.51) | 106 (21.29) | 6 (1.20) | 0.665 | 878 (88.15) | 118 (11.85) | 0.714 | 0.9533 | ||
Good CCC | 105 | 84 (80) | 19 (18.10) | 2 (1.90) | 187 (89.05) | 23 (10.95) | |||||
rs833061 | Â | Â | CC | CT | TT | Â | C | T | Â | Â | |
Poor CCC | 526 | 124 (23.57) | 268 (50.95) | 134 (25.48) | 0.471 | 516 (49.05) | 536 (50.95) | 0.232 | 0.6392 | ||
Good CCC | 121 | 33 (27.27) | 63 (52.07) | 25 (20.66) | 129 (53.31) | 113 (46.69) | |||||
KDR | rs1870377 | Â | Â | TT | AT | AA | Â | T | A | Â | Â |
Poor CCC | 496 | 291 (58.67) | 178 (35.89) | 27 (5.44) | 0.613 | 760 (76.61) | 232 (23.39) | 0.328 | 0.8991 | ||
Good CCC | 106 | 67 (63.21) | 35 (33.02) | 4 (3.77) | 169 (79.72) | 43 (20.28) | |||||
rs2305948 | Â | Â | CC | CT | TT | Â | C | T | Â | Â | |
Poor CCC | 582 | 487 (83.68) | 88 (15.12) | 7 (1.20) | 0.199 | 1062 (91.24) | 102 (8.76) | 0.207 | 0.3210 | ||
Good CCC | 153 | 120 (78.43) | 32 (20.92) | 1 (0.65) | 272 (88.89) | 34 (11.11) | |||||
rs2071559 | Â | Â | TT | CT | CC | Â | T | C | Â | Â | |
Poor CCC | 544 | 147 (27.02) | 276 (50.74) | 121 (22.24) | 0.319 | 570 (52.39) | 518 (47.61) | 0.140 | 0.8355 | ||
Good CCC | 129 | 29 (22.48) | 64 (49.61) | 36 (27.91) | 122 (47.29) | 136 (52.71) | |||||
CCL2 | rs1024611 | Â | Â | AA | AG | GG | Â | A | G | Â | Â |
Poor CCC | 576 | 332 (57.64) | 210 (36.46) | 34 (5.90) | 0.221 | 874 (75.87) | 278 (24.13) | 0.826 | 0.3186 | ||
Good CCC | 153 | 94 (61.44) | 46 (30.06) | 13 (8.50) | 234 (76.47) | 72 (23.53) | |||||
rs1024610 | Â | Â | AA | AT | TT | Â | A | T | Â | Â | |
Poor CCC | 516 | 312 (60.47) | 180 (34.88) | 24 (4.65) | 0.516 | 804 (77.91) | 228 (22.09) | 0.715 | 0.6077 | ||
Good CCC | 112 | 68 (60.71) | 36 (32.15) | 8 (7.14) | 172 (76.79) | 52 (23.21) | |||||
rs2857657 | Â | Â | CC | CG | GG | Â | C | G | Â | Â | |
Poor CCC | 511 | 309 (60.47) | 181 (35.42) | 21 (4.11) | 0.365 | 799 (78.18) | 223 (21.82) | 0.832 | 0.8093 | ||
Good CCC | 111 | 71 (63.96) | 33 (29.73) | 7 (6.31) | 175 (78.83) | 47 (21.17) | |||||
rs2857654 | Â | Â | CC | AC | AA | Â | C | A | Â | Â | |
Poor CCC | 580 | 336 (57.93) | 211 (36.38) | 33 (5.69) | 0.248 | 883 (76.12) | 277 (23.88) | 0.993 | 0.4284 | ||
Good CCC | 153 | 93 (60.78) | 47 (30.72) | 13 (8.50) | 233 (76.14) | 73 (23.86) | |||||
NOS3 | rs1799983 | Â | Â | GG | GT | TT | Â | G | T | Â | Â |
Poor CCC | 513 | 211 (41.13) | 216 (42.11) | 86 (16.76) | 0.596 | 638 (62.18) | 388 (37.82) | 0.686 | 0.0157* | ||
Good CCC | 110 | 46 (41.82) | 48 (43.64) | 16 (14.54) | 140 (63.64) | 80 (36.36) | |||||
ICAM1 | rs5498 | Â | Â | AA | AG | GG | Â | A | G | Â | Â |
Poor CCC | 516 | 136 (26.36) | 246 (47.67) | 134 (25.97) | 0.308 | 518 (50.19) | 514 (49.81) | 0.958 | 0.1039 | ||
Good CCC | 112 | 33 (29.46) | 46 (41.08) | 33 (29.46) | 112 (50.00) | 112 (50.00) | |||||
rs3093030 | Â | Â | CC | CT | TT | Â | C | T | Â | Â | |
Poor CCC | 517 | 134 (25.92) | 248 (47.97) | 135 (26.11) | 0.415 | 516 (49.90) | 518 (50.10) | 0.883 | 0.1535 | ||
Good CCC | 112 | 33 (29.46) | 47 (41.97) | 32 (28.57) | 113 (50.45) | 111 (49.55) | |||||
TGFB1 | rs1800469 | Â | Â | GG | GA | AA | Â | G | A | Â | Â |
Poor CCC | 483 | 198 (50.00) | 228 (47.20) | 57 (11.80) | 0.696 | 624 (64.60) | 342 (35.40) | 0.979 | 0.8844 | ||
Good CCC | 100 | 43 (43.00) | 43 (43.00) | 14 (14.00) | 129 (64.50) | 71 (35.50) | |||||
CD53 | rs6679497 | Â | Â | GG | GA | AA | Â | G | A | Â | Â |
Poor CCC | 483 | 198 (41.00) | 228 (47.20) | 57 (11.80) | 0.826 | 624 (64.60) | 342 (35.40) | 0.572 | 0.6712 | ||
Good CCC | 100 | 43 (43.00) | 43 (43.00) | 14 (14.00) | 129 (64.50) | 71 (35.50) | |||||
POSTN | rs3829365 | Â | Â | GG | GC | CC | Â | G | C | Â | Â |
Poor CCC | 405 | 357 (88.15) | 22 (5.43) | 26 (6.42) | 0.795 | 736 (90.86) | 74 (9.14) | 0.535 | 0.0000* | ||
Good CCC | 76 | 69 (90.79) | 3 (3.95) | 4 (5.26) | 141 (92.76) | 11 (7.24) | |||||
rs1028728 | Â | Â | AA | AT | TT | Â | A | T | Â | Â | |
Poor CCC | 389 | 242 (62.21) | 128 (32.91) | 19 (4.88) | 0.230 | 612 (78.66) | 166 (21.34) | 0.105 | 0.7373 | ||
Good CCC | 77 | 54 (70.13) | 22 (28.57) | 1 (1.30) | 130 (84.42) | 24 (15.58) | |||||
LGALS2 | rs7291467 | Â | Â | AA | AG | GG | Â | A | G | Â | Â |
Poor CCC | 581 | 160 (27.54) | 292 (50.26) | 129 (22.20) | 0.106 | 612 (52.67) | 550 (47.33) | 0.080 | 0.9589 | ||
Good CCC | 151 | 37 (24.50) | 68 (45.03) | 46 (30.47) | 142 (47.02) | 160 (52.98) | |||||
HIF1A | rs11549465 | Â | Â | CC | CT | TT | Â | C | T | Â | Â |
Poor CCC | 518 | 402 (77.60) | 111 (21.43) | 5 (0.97) | 0.563 | 915 (88.32) | 121 (11.68) | 0.474 | 0.4122 | ||
Good CCC | 112 | 84 (75) | 26 (23.21) | 2 (1.79) | 194 (86.61) | 30 (13.39) | |||||
rs2057482 | Â | Â | CC | CT | TT | Â | C | T | Â | Â | |
Poor CCC | 497 | 339 (68.21) | 148 (29.78) | 10 (2.01) | 0.490 | 826 (83.10) | 168 (16.90) | 0.328 | 0.1151 | ||
Good CCC | 111 | 70 (63.06) | 38 (34.24) | 3 (2.70) | 178 (80.18) | 44 (19.82) |