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Table 3 Association of genotype and allele distribution of examined polymorphisms with CAD patients with poor and good CCC

From: Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization

Gene dbSNP ID Patients n Genotype count (frequency) P valuea Allele count (frequency) P valueb HWE P
VEGFA rs2010963    GG GC CC   G C   
Poor CCC 531 247 (46.52) 224 (42.18) 60 (11.30) 0.5760 718 (67.61) 344 (32.39) 0.495 0.8216
Good CCC 121 50 (41.32) 58 (47.93) 13 (10.75) 158 (65.29) 84 (34.71)
rs1570360    GG GA AA   G A   
Poor CCC 451 207 (45.90) 197 (43.68) 47 (10.42) 0.782 611 (67.74) 291 (32.26) 0.521 0.8494
Good CCC 97 47 (48.45) 42 (43.30) 8 (8.25) 136 (70.10) 58 (29.90)
rs699947    CC AC AA   C A   
Poor CCC 494 138 (27.94) 245 (49.59) 111 (22.47) 0.816 521 (52.73) 467 (47.27) 0.968 0.5199
Good CCC 104 31 (29.81) 48 (46.15) 25 (24.04) 110 (52.90) 98 (47.12)
rs3025039    CC CT TT   C T   
Poor CCC 498 386 (77.51) 106 (21.29) 6 (1.20) 0.665 878 (88.15) 118 (11.85) 0.714 0.9533
Good CCC 105 84 (80) 19 (18.10) 2 (1.90) 187 (89.05) 23 (10.95)
rs833061    CC CT TT   C T   
Poor CCC 526 124 (23.57) 268 (50.95) 134 (25.48) 0.471 516 (49.05) 536 (50.95) 0.232 0.6392
Good CCC 121 33 (27.27) 63 (52.07) 25 (20.66) 129 (53.31) 113 (46.69)
KDR rs1870377    TT AT AA   T A   
Poor CCC 496 291 (58.67) 178 (35.89) 27 (5.44) 0.613 760 (76.61) 232 (23.39) 0.328 0.8991
Good CCC 106 67 (63.21) 35 (33.02) 4 (3.77) 169 (79.72) 43 (20.28)
rs2305948    CC CT TT   C T   
Poor CCC 582 487 (83.68) 88 (15.12) 7 (1.20) 0.199 1062 (91.24) 102 (8.76) 0.207 0.3210
Good CCC 153 120 (78.43) 32 (20.92) 1 (0.65) 272 (88.89) 34 (11.11)
rs2071559    TT CT CC   T C   
Poor CCC 544 147 (27.02) 276 (50.74) 121 (22.24) 0.319 570 (52.39) 518 (47.61) 0.140 0.8355
Good CCC 129 29 (22.48) 64 (49.61) 36 (27.91) 122 (47.29) 136 (52.71)
CCL2 rs1024611    AA AG GG   A G   
Poor CCC 576 332 (57.64) 210 (36.46) 34 (5.90) 0.221 874 (75.87) 278 (24.13) 0.826 0.3186
Good CCC 153 94 (61.44) 46 (30.06) 13 (8.50) 234 (76.47) 72 (23.53)
rs1024610    AA AT TT   A T   
Poor CCC 516 312 (60.47) 180 (34.88) 24 (4.65) 0.516 804 (77.91) 228 (22.09) 0.715 0.6077
Good CCC 112 68 (60.71) 36 (32.15) 8 (7.14) 172 (76.79) 52 (23.21)
rs2857657    CC CG GG   C G   
Poor CCC 511 309 (60.47) 181 (35.42) 21 (4.11) 0.365 799 (78.18) 223 (21.82) 0.832 0.8093
Good CCC 111 71 (63.96) 33 (29.73) 7 (6.31) 175 (78.83) 47 (21.17)
rs2857654    CC AC AA   C A   
Poor CCC 580 336 (57.93) 211 (36.38) 33 (5.69) 0.248 883 (76.12) 277 (23.88) 0.993 0.4284
Good CCC 153 93 (60.78) 47 (30.72) 13 (8.50) 233 (76.14) 73 (23.86)
NOS3 rs1799983    GG GT TT   G T   
Poor CCC 513 211 (41.13) 216 (42.11) 86 (16.76) 0.596 638 (62.18) 388 (37.82) 0.686 0.0157*
Good CCC 110 46 (41.82) 48 (43.64) 16 (14.54) 140 (63.64) 80 (36.36)
ICAM1 rs5498    AA AG GG   A G   
Poor CCC 516 136 (26.36) 246 (47.67) 134 (25.97) 0.308 518 (50.19) 514 (49.81) 0.958 0.1039
Good CCC 112 33 (29.46) 46 (41.08) 33 (29.46) 112 (50.00) 112 (50.00)
rs3093030    CC CT TT   C T   
Poor CCC 517 134 (25.92) 248 (47.97) 135 (26.11) 0.415 516 (49.90) 518 (50.10) 0.883 0.1535
Good CCC 112 33 (29.46) 47 (41.97) 32 (28.57) 113 (50.45) 111 (49.55)
TGFB1 rs1800469    GG GA AA   G A   
Poor CCC 483 198 (50.00) 228 (47.20) 57 (11.80) 0.696 624 (64.60) 342 (35.40) 0.979 0.8844
Good CCC 100 43 (43.00) 43 (43.00) 14 (14.00) 129 (64.50) 71 (35.50)
CD53 rs6679497    GG GA AA   G A   
Poor CCC 483 198 (41.00) 228 (47.20) 57 (11.80) 0.826 624 (64.60) 342 (35.40) 0.572 0.6712
Good CCC 100 43 (43.00) 43 (43.00) 14 (14.00) 129 (64.50) 71 (35.50)
POSTN rs3829365    GG GC CC   G C   
Poor CCC 405 357 (88.15) 22 (5.43) 26 (6.42) 0.795 736 (90.86) 74 (9.14) 0.535 0.0000*
Good CCC 76 69 (90.79) 3 (3.95) 4 (5.26) 141 (92.76) 11 (7.24)
rs1028728    AA AT TT   A T   
Poor CCC 389 242 (62.21) 128 (32.91) 19 (4.88) 0.230 612 (78.66) 166 (21.34) 0.105 0.7373
Good CCC 77 54 (70.13) 22 (28.57) 1 (1.30) 130 (84.42) 24 (15.58)
LGALS2 rs7291467    AA AG GG   A G   
Poor CCC 581 160 (27.54) 292 (50.26) 129 (22.20) 0.106 612 (52.67) 550 (47.33) 0.080 0.9589
Good CCC 151 37 (24.50) 68 (45.03) 46 (30.47) 142 (47.02) 160 (52.98)
HIF1A rs11549465    CC CT TT   C T   
Poor CCC 518 402 (77.60) 111 (21.43) 5 (0.97) 0.563 915 (88.32) 121 (11.68) 0.474 0.4122
Good CCC 112 84 (75) 26 (23.21) 2 (1.79) 194 (86.61) 30 (13.39)
rs2057482    CC CT TT   C T   
Poor CCC 497 339 (68.21) 148 (29.78) 10 (2.01) 0.490 826 (83.10) 168 (16.90) 0.328 0.1151
Good CCC 111 70 (63.06) 38 (34.24) 3 (2.70) 178 (80.18) 44 (19.82)
  1. aFisher’s exact test was used to evaluate differences between genotype groups. bPearson’s chi-squared, χ2, was used for to evaluate the allele distribution. *p <0.05 was considered as statistically significant