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Table 3 Multivariable Cox Regression analyses for all-cause mortality and AHF related rehospitalization at 5 years in all patients (n = 401)

From: Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I

 

All-cause mortality

AHF-related reospitalization

 

hFABP

Troponin I

hFABP

Troponin I

 

HR

95 % CI

p Value

HR

95 % CI

p Value

HR

95 % CI

p Value

HR

95 % CI

p Value

Age

1.033

1.016–1.050

0.001

1.036

1.019–1.054

0.001

1.012

0.989–1.034

0.301

1.012

0.989–1.034

0.296

Sex

1.261

0.844–1.884

0.259

1.193

0.788–1.804

0.405

1.012

0.593–1.726

0.966

0.989

0.574–1.705

0.968

NYHA functional class

1.107

0.826–1.485

0.496

1.091

0.816–1.458

0.556

1.799

1.257–2.576

0.001

1.765

1.236–2.519

0.002

Left ventricular function

1.227

0.964–1.562

0.096

1.267

0.993–1.616

0.057

1.013

0.756–1.359

0.930

0.995

0.745–1.329

0.973

Coronary artery disease

0.843

0.555–1.280

0.422

0.907

0.595–1.380

0.648

1.438

0.824–2.509

0.201

1.469

0.839–2.569

0.178

Diabetes mellitus

1.194

0.798–1.786

0.389

1.113

0.747–1.660

0.598

1.757

1.056–2.924

0.030

1.623

0.979–2.693

0.061

Creatinine (mg/dl)

0.783

0.470–1.305

0.348

0.849

0.515–1.398

0.519

0.797

0.414–1.533

0.496

0.859

0.451–1.636

0.643

Sodium (mmol/l)

0.974

0.939–1.011

0.160

0.976

0.941–1.012

0.183

1.039

0.978–1.104

0.212

1.039

0.978–1.103

0.218

Hemoglobin (g/dl)

0.860

0.776–0.954

0.005

0.868

0.782–0.962

0.007

1.000

0.874–1.145

0.997

0.996

0.870–1.141

0.957

ACEI / ARB treatment

0.707

0.478–1.045

0.082

0.714

0.484–1.052

0.089

1.647

0.969–2.799

0.066

1.651

0.967–2.820

0.066

Beta-blocker treatment

0.844

0.559–1.275

0.421

0.853

0.567–1.282

0.443

1.066

0.629–1.805

0.813

1.044

0.616–1.769

0.873

LogNT-proBNP (ng/l)

1.445

1.254–1.665

0.001

1.525

1.325–1.755

0.001

1.209

0.993–1.472

0.058

1.251

1.027–1.523

0.026

hFABP (10 ng/ml)

1.020

1.020–0.998

0.081

-

-

-

1.034

1.001–1.069

0.047

-

-

-

Troponin I (μg/l)

-

-

-

0.857

0.696–1.057

0.148

-

-

-

0.982

0.914–1.055

0.620

  1. The logarithmic function of NT-proBNP and hFABP per every 10 ng/ml change were used in Cox Models. Significant p values (p<0.05) are written in bold type. Dashes indicate non applicable
  2. HR hazard ratio, CI confidence interval