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Table 3 Multivariable Cox Regression analyses for all-cause mortality and AHF related rehospitalization at 5 years in all patients (n = 401)

From: Ischemic biomarker heart-type fatty acid binding protein (hFABP) in acute heart failure - diagnostic and prognostic insights compared to NT-proBNP and troponin I

  All-cause mortality AHF-related reospitalization
  hFABP Troponin I hFABP Troponin I
  HR 95 % CI p Value HR 95 % CI p Value HR 95 % CI p Value HR 95 % CI p Value
Age 1.033 1.016–1.050 0.001 1.036 1.019–1.054 0.001 1.012 0.989–1.034 0.301 1.012 0.989–1.034 0.296
Sex 1.261 0.844–1.884 0.259 1.193 0.788–1.804 0.405 1.012 0.593–1.726 0.966 0.989 0.574–1.705 0.968
NYHA functional class 1.107 0.826–1.485 0.496 1.091 0.816–1.458 0.556 1.799 1.257–2.576 0.001 1.765 1.236–2.519 0.002
Left ventricular function 1.227 0.964–1.562 0.096 1.267 0.993–1.616 0.057 1.013 0.756–1.359 0.930 0.995 0.745–1.329 0.973
Coronary artery disease 0.843 0.555–1.280 0.422 0.907 0.595–1.380 0.648 1.438 0.824–2.509 0.201 1.469 0.839–2.569 0.178
Diabetes mellitus 1.194 0.798–1.786 0.389 1.113 0.747–1.660 0.598 1.757 1.056–2.924 0.030 1.623 0.979–2.693 0.061
Creatinine (mg/dl) 0.783 0.470–1.305 0.348 0.849 0.515–1.398 0.519 0.797 0.414–1.533 0.496 0.859 0.451–1.636 0.643
Sodium (mmol/l) 0.974 0.939–1.011 0.160 0.976 0.941–1.012 0.183 1.039 0.978–1.104 0.212 1.039 0.978–1.103 0.218
Hemoglobin (g/dl) 0.860 0.776–0.954 0.005 0.868 0.782–0.962 0.007 1.000 0.874–1.145 0.997 0.996 0.870–1.141 0.957
ACEI / ARB treatment 0.707 0.478–1.045 0.082 0.714 0.484–1.052 0.089 1.647 0.969–2.799 0.066 1.651 0.967–2.820 0.066
Beta-blocker treatment 0.844 0.559–1.275 0.421 0.853 0.567–1.282 0.443 1.066 0.629–1.805 0.813 1.044 0.616–1.769 0.873
LogNT-proBNP (ng/l) 1.445 1.254–1.665 0.001 1.525 1.325–1.755 0.001 1.209 0.993–1.472 0.058 1.251 1.027–1.523 0.026
hFABP (10 ng/ml) 1.020 1.020–0.998 0.081 - - - 1.034 1.001–1.069 0.047 - - -
Troponin I (μg/l) - - - 0.857 0.696–1.057 0.148 - - - 0.982 0.914–1.055 0.620
  1. The logarithmic function of NT-proBNP and hFABP per every 10 ng/ml change were used in Cox Models. Significant p values (p<0.05) are written in bold type. Dashes indicate non applicable
  2. HR hazard ratio, CI confidence interval