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Table 2 Summarized data of measured biomarkers

From: Molecular mechanisms behind progressing chronic inflammatory dilated cardiomyopathy

Variable Inflammation negative group Inflammation positive group  
Total No. of pts. Value Total No. of pts. Value p Value
Markers of inflammation in serum      
 TNF-α (pg/mL) 8 7.9313 ± 0.5106 21 14.2819 ± 5.0280 0.223
 IL-6 (pg/mL) 8 3.3938 ± 0.8554 21 11.4038 ± 3.3614 0.031*
 IL-1β (pg/mL) 8 5.0000 ± 0.0000 21 4.7619 ± 0.2381 0.329
 CRP (μg/mL) 8 7.6875 ± 5.0460 19 21.5563 ± 6.9633 0.066¡
Markers of apoptosis in serum      
 Bcl2 (ng/mg protein) 10 0.0288 ± 0.0288 22 0.0536 ± 0.0455 0.889¡
 Bax (ng/mg protein) 10 2.152717 ± 0.24 22 2.3354 ± 0.1606 0.535
 Caspase-9 (ng/mg protein) 10 0.012955 ± 0.0013 22 0.0808 ± 0.0283 0.038*
 Caspase-8 (ng/mg protein) 10 0.001 ± 0.0001 22 0.0031 ± 0.0009 0.043
 Caspase-3 (ng/mg protein) 10 0.0029 ± 0.0022 22 0.0105 ± 0.0023 0.025*
 APO1/Fas/CD95 (ng/mg protein) 10 0.0000 ± 0.0000 22 0.00004 ± 0.00004 0.857¡
 FasL (ng/mg protein) 10 0.0000 ± 0.0000 22 0.0000 ± 0.0000 N.A.
 HSP60 (ng/mg protein) 10 0.0419 ± 0.0253 22 0.3760 ± 0.1468 0.035*
Markers of apoptosis in biopsy      
 Bcl2 (ng/mg protein) 10 83.5523 ± 26.2936 21 63.8790 ± 17.2137 0.540
 Bax (ng/mg protein) 10 5.6452 ± 2.6905 21 6.8873 ± 3.7924 0.724¡
 Caspase-9 (ng/mg protein) 10 29.6575 ± 12.5969 21 38.7122 ± 9.6108 0.950¡
 Caspase-8 (ng/mg protein) 10 0.9483 ± 0.1640 21 1.1611 ± 0.1962 0.413
 Caspase-3 (ng/mg protein) 10 0.2503 ± 0.0773 21 0.2586 ± 0.0649 0.935
 APO1/Fas/CD95 (ng/mg protein) 10 3.4651 ± 0.6568 21 4.1921 ± 0.6607 0.443
 FasL (ng/mg protein) 10 4.5550 ± 1.3594 21 4.0588 ± 1.1083 0.780
 HSP-60 (ng/mg protein) 10 24.1262 ± 6.9102 21 19.2656 ± 4.5617 0.565
Marker of heart tissue contraction in serum      
 hsTnT (pg/mL) 8 35.4988 ± 9.0908 20 66.4145 ± 26.9755 0.289
Markers of extracellular matrix degradation in serum      
 MMP9 (ng/mg protein) 10 1.3867 ± 0.0674 22 1.5261 ± 0.0508 0.115
 TIMP1 (ng/mg protein) 10 5.9610 ± 0.3597 22 6.1223 ± 0.1497 0.686
 MMP9/TIMP1 10 0.2355 ± 0.0090 22 0.2511 ± 0.0086 0.223
Markers of extracellular matrix degradation in biopsy      
 MMP9 (ng/mg protein) 10 2.3698 ± 1.1931 21 2.7630 ± 0.9394 0.798
 TIMP1 (ng/mg protein) 10 9.4917 ± 1.7605 21 7.8056 ± 1.4029 0.462
 MMP9/TIMP1 10 0.1931 ± 0.0729 21 0.4760 ± 0.1048 0.035*
 Frequency of viral genome 5 50% 11 50%  
 BNP (pg/mL) 10 1277.8500 ± 428.5054 22 1603.2591 ± 276.3777 0.532
  1. Data are presented as the means ± SE. *Significant at 0.05 level. ¡ Wilcoxon–Mann–Whitney rank sum nonparametric test. Abbreviations: TNF-α - tumor necrosis factor α; IL-6 – interleukin-6; IL-1β – interleukin 1β; Bcl-2 – B-cell lymphoma 2 protein; Bax – Bcl-2–associated X protein; Hsp60 – heat shock protein 60; MMP9 – matrix metalloproteinase 9; TIMP1 – tissue inhibitor of matrix metalloproteinase 1; TNF-a – tumor necrosis factor-alfa; IL-1β – interleukin 1 beta; IL-6 – interleukin 6; hs TnT – high sensitivity troponin T; CRP – C-reactive protein, BNP- B-type natriuretic protein; N.A. – not available.