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Table 3 Concentration of cholesterol in aorta and morphological analyses of aortic sinus of guinea pigs treated with the drug or placebo (control group)1

From: A-002 (Varespladib), a phospholipase A2inhibitor, reduces atherosclerosis in guinea pigs

Parameter

Control

A-002

% Reduction from control

p-value

Aorta Cholesterol (mg/g)

8.34 ± 0.78

6.05 ± 0.32

27%

0.025

Aortic sinus plaque formation (score)

2.1 ± 0.260

1.6 ± 0.318

24%

0.221

Plaque:lumen ratio (%)

4.27 ± 0.708

2.63 ± 0.317

38%

0.146

Plaque:IEL ratio (%)

4.04 ± 0.651

2.55 ± 0.302

37%

0.154

  1. 1 Values are expressed as mean ± SEM for n = 10 guinea pigs per group.