From: A-002 (Varespladib), a phospholipase A2inhibitor, reduces atherosclerosis in guinea pigs
Parameter | Control | A-002 | % Reduction from control | p-value |
---|---|---|---|---|
Aorta Cholesterol (mg/g) | 8.34 ± 0.78 | 6.05 ± 0.32 | 27% | 0.025 |
Aortic sinus plaque formation (score) | 2.1 ± 0.260 | 1.6 ± 0.318 | 24% | 0.221 |
Plaque:lumen ratio (%) | 4.27 ± 0.708 | 2.63 ± 0.317 | 38% | 0.146 |
Plaque:IEL ratio (%) | 4.04 ± 0.651 | 2.55 ± 0.302 | 37% | 0.154 |