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Table 2 Plasma concentrations total, LDL and HDL cholesterol of guinea pigs treated with the drug or placebo (control group)1

From: A-002 (Varespladib), a phospholipase A2inhibitor, reduces atherosclerosis in guinea pigs

Plasma Lipids

Control

A-002

P Value

Total Cholesterol (mg/dL)

237.2 ± 21.2

249.1 ± 14.9

0.65

Triglycerides (mg/dL)

48.5 ± 4.3

54.5 ± 4.9

0.372

HDL-Cholesterol (mg/dL)

17.6 ± 3.3

19.3 ± 2.5

0.696

LDL-Cholesterol (mg/dL)

209.8 ± 22.1

218.8 ± 17.1

0.749

  1. 1 Values are expressed as mean ± SE for n = 10 guinea pigs per group.