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Table 2 Mortality relative to studied variables including information derived from exploratory analysis (Cox proportional hazards model)

From: Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure

Variables

p

Hazard ratio

95% Confidence interval

Serum sodium

< 0.001

0.94

(0.91; 0.96)

Serum creatinine

< 0.001

1.47

(1.27; 1.69)

Etiology

0.09

0.91

(0.81; 1.02)

Ethnicity

0.73

0.97

(0.80; 1.17)

Gln27Glu #

0.01

5.48

(1.50; 20.08)

Age

< 0.001

1.03

(1.02; 1.05)

Age * Gln27Glu #

0.004

0.97

(0.95; 0.99)

Baseline beta-blocker use

0.001

2.30

(1.43; 3.71)

  1. # dominant model (GlnGln genotype reference versus GlnGlu + GluGlu genotypes)
  2. Serum sodium, serum creatinine and age included as continuous variables
  3. Etiology (1. Chagasic, 2 Idiopathic, 3 Hypertensive, 4 Isquemic, 5 Heart failure due to valve disease)