Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease

Table 1 Physical and Biochemical Characteristics in the Study Subjects

Variable	Control n = 10	Angina n = 15	CABG n = 10
Age (years)	62 ± 13	64 ± 13	70 ± 5
Smokers	2	4	1
SBP (mmHg)	125 ± 9	142 ± 15*	140 ± 14*
DBP (mmHg)	72 ± 8	76 ± 9	78 ± 12
Total cholesterol (mg/dl)	4.9 ± 1.6	5.3 ± 1.2	4.4 ± 2.4
LDL (mg/dl)	3.5 ± 0.7	3.5 ± 1.1	2.5 ± 1.6
HDL (mg/dl)	1.5 ± 0.5	1.5 ± 0.4	1.3 ± 0.5
Triglycerides (mg/dl)	1.5 ± 0.9	1.7 ± 1.0	1.9 ± 0.9
Apo lipoprotein A (mg/dl)	1.5 ± 0.3	1.6 ± 0.2	1.3 ± 0.5
Apo lipoprotein B (mg/dl)	0.9 ± 0.2	1.0 ± 0.3	0.9 ± 0.3
NYHA class
I	10	10	4
II	0	0	4
III	0	0	2
IV	0	0	0
NT pro-BNP (ng/L)	106 ± 112	218 ± 243	1626 ± 2157*
C reactive protein (mg/dl)	2.1 ± 1.9	6.2 ± 15.3*	6.9 ± 6.1*
Beta blockers (n)	0	6	7
Statins (n)	0	5	8
ARB or ACEI (n)	0	3	6
HbA1c (%)	4.5 ± 0.5	4.7 ± 0.4	4.7 ± 0.8
BMI (kg/m²)	28 ± 2	29 ± 5	27 ± 3

Values are expressed as mean ± SD. Statistical analysis was performed using ANOVA with Dunnet's post-test for multiple comparisons. Significance was defined as P < 0.05 (*). Abbreviations are: CABG, coronary artery bypass graft surgery; SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL, low-density lipoprotein cholesterol; HDL, high-density lipoprotein cholesterol; NYHA, New York Heart Association Functional Classification; NT-proBNP, N-terminal pro B-type natriuretic peptide; ARB, angiotensin receptor blockers; ACEI, angiotensin converting enzyme inhibitors and BMI, body mass index.

ISSN: 1471-2261