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Figure 1 | BMC Cardiovascular Disorders

Figure 1

From: Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline

Figure 1

Effect of L-norvaline on TNFα-induced expression of VCAM-1, ICAM-1, and E-selectin. (A) Stimulation of HUVECs with TNFα (10 ng/ml, 4 hours) increased expression of VCAM-1, ICAM-1, and E-selectin, which was significantly reduced by L-norvaline in a concentration-dependent manner. Tubulin in bottom panel served as loading control. (B) Quantification of the signals shown in panel A. Representative data from five independent experiments are reported as mean ± SEM. Values are given as percentage relative to stimulation with TNFα. *p < 0.05, **p < 0.01, ***p < 0.001 vs. stimulation with TNFα. o/n = overnight.

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BMC Cardiovascular Disorders

ISSN: 1471-2261

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