From: ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model
Study 2 | |||||
---|---|---|---|---|---|
Sham operation (0 NX) | 5/6 NX | ||||
No enalapril | Enalapril | ||||
Variable | Unit | (n = 7) | (n = 8) | (n = 13) | P |
Body weight | g | 32.1 ± 2.0 | 27.3 ± 2.1a | 27.4 ± 2.0 | < 0.001 |
Systolic blood pressure | mmHg | 112.9 ± 6.1 | 116.8 ± 4.6 | 105.2 ± 7.2b | < 0.005 |
B-hemoglobin | mmol/L | 9.60 ± 0.83 | 7.31 ± 0.97a | 6.99 ± 0.66 | < 0.001 |
P-urea | mmol/L | 11.9 ± 1.1 | 28.6 ± 5.4a | 26.3 ± 6.2 | < 0.001 |
P-creatinine | mmol/L | 0.016 ± 0.002 | 0.030 ± 0.007a | 0.025 ± 0.006 | < 0.001 |
P-phosphate | mmol/L | 2.47 ± 0.47 | 2.78 ± 0.65 | 2.54 ± 0.39 | NS |
P-calcium | mmol/L | 2.70 ± 0.21 | 2.95 ± 0.41 | 2.61 ± 0.07 | < 0.05 |
P-Ca × P | mmol2/L2 | 6.65 ± 1.45 | 8.40 ± 3.19 | 6.63 ± 0.99 | NS |
P-cholesterol | mmol/L | 16.3 ± 2.4 | 16.6 ± 3.3 | 13.5 ± 2.9b | < 0.05 |
Aortic plaque area fraction | % | 0.10 ± 0.07 | 0.23 ± 0.08a | 0.11 ± 0.04b | < 0.005 |