Skip to main content
Figure 5 | BMC Cardiovascular Disorders

Figure 5

From: ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model

Figure 5

Effects of uremia and enalapril treatment on the thickness of the aortic valve leaflets in apoE -/- mice. (A) Effect of 22 weeks of uremia on the thickness of the aortic valve leaflets (Study 1). Three different groups were compared: unoperated (0 NX), unilaterally nephrectomized (1/2 NX) and subtotally nephrectomized (5/6 NX) mice. (B) Effect of 32 weeks of enalapril treatment on the thickness of the aortic valve leaflets induced by uremia lasting for 36 weeks (Study 2). Three groups of mice are shown: sham-operated (0 NX), and subtotally nephrectomized (5/6 NX) mice without and with the drug intervention. Each dot represents a value obtained from an individual mouse. Means are shown as diamonds and standard deviations as vertical bars. Note that, at the time of sacrifice, all the mice in Study 1 were 29 weeks old and all the mice in Study 2 were 46 weeks old.

Back to article page