Skip to main content
Figure 2 | BMC Cardiovascular Disorders

Figure 2

From: ACE inhibition attenuates uremia-induced aortic valve thickening in a novel mouse model

Figure 2

Histological cross-sections of the aortic root showing three levels of cutting of the aortic valve. The sections were chosen to show (A) the commissural level (0 μm), and the levels (B) -80 μm and (C) -160 μm towards the base of aortic valve. Note that at 0 μm, only the leaflet commissures are visible, demonstrating that the free edge of the leaflet is below the 0 μm level. The maximal leaflet thickness (measured at the nodule of Arantius located at the center of a leaflet) is smaller at -160 μm than at -80 μm, reflecting the gradual thickening of the nodule towards the free edge of the leaflet. The sections were collected starting from the base of the valve and moving towards the commissural level, which is defined as the reference level (0 μm) in this stack of sections. Panel (D) illustrates the cutting levels in the aortic root. The sample is derived from a uremic mouse (Study 1). Photographed using 4× magnification.

Back to article page