Figure 3From: Rapid short-duration hypothermia with cold saline and endovascular cooling before reperfusion reduces microvascular obstruction and myocardial infarct size (a) Size of area at risk (AAR) by SPECT. There was no difference in AAR between the different groups. (b) Infarct size (IS) measured by ex-vivo MRI as a percentage of area at risk (AAR) by SPECT in the two groups. Pre-reperfusion hypothermia causes a 43% relative reduction in infarct size compared to post-reperfusion hypothermia and by 39% compared to normothermia. (c) Infarct size (IS) measured by ex vivo MRI, expressed as a percentage of the left ventricular mass. (d) Microvascular obstruction measured by ex vivo MRI, expressed as a percentage of the infarct size. Pre-reperfusion hypothermia totally abolished microvascular obstruction. Post-reperfusion hypothermia significantly decreased the extent of micovascular obstruction compared to normothermia. (* = p < 0.05, ** = p < 0.01, *** = p < 0.001). Data are expressed as mean ± SEM.Back to article page