Table 4 Associations between Ser carriage and the PGC1α Gly482Ser polymorphism and diastolic dysfunction, in males and females.
From: The PPARGC1AGly482Ser polymorphism is associated with left ventricular diastolic dysfunction in men
Gly/Gly | Gly/Ser + Ser/Ser | P | ||
|---|---|---|---|---|
Males | N = 214 | N = 285 | ||
Diastolic dysfunction, N (%) | 42 (19.9) | 37 (13.8) | ||
Covariates | OR | OR | (95% CI) | |
Age | 1.0 | 0.59 | (0.34 – 1.02) | 0.059 |
Age, body mass index | 1.0 | 0.54 | (0.31 – 0.94) | 0.031 |
Age, low leisure-time physical activity | 1.0 | 0.60 | (0.35 – 1.05) | 0.073 |
Age, body mass index, low leisure-time physical activity | 1.0 | 0.55 | (0.32 – 0.97) | 0.038 |
Age, hypertension | 1.0 | 0.58 | (0.33 – 1.01) | 0.054 |
Age, diabetes | 1.0 | 0.56 | (0.32 – 0.98) | 0.043 |
Age, hypertension, diabetes | 1.0 | 0.56 | (0.32 – 0.99) | 0.044 |
Age, body mass index, low leisure-time physical activity, hypertension, diabetes | 1.0 | 0.52 | (0.29 – 0.92) | 0.026 |
Gly/Gly | Gly/Ser+Ser/Ser | P | ||
Females | N = 229 | N = 304 | ||
Diastolic dysfunction, N (%) | 29 (11.7) | 29 (13.6) | ||
Covariates | OR | OR | (95% CI) | |
Age | 1.0 | 1.08 | (0.57 – 2.04) | 0.825 |
Age, body mass index | 1.0 | 1.01 | (0.52 – 1.96) | 0.968 |
Age, low leisure-time physical activity | 1.0 | 1.13 | (0.59 – 2.16) | 0.717 |
Age, body mass index, low leisure-time physical activity | 1.0 | 1.06 | (0.54 – 2.07) | 0.867 |
Age, hypertension | 1.0 | 1.27 | (0.64 – 2.50) | 0.492 |
Age, diabetes | 1.0 | 1.13 | (0.59 – 2.16) | 0.772 |
Age, hypertension, diabetes | 1.0 | 1.29 | (0.65 – 2.56) | 0.463 |
Age, body mass index, low leisure-time physical activity, hypertension, diabetes | 1.0 | 1.24 | (0.62 – 2.51) | 0.539 |