Skip to main content

Table 2 Hazard ratios of a MI exploring a recessive effect of the Asp 298 polymorphism, with Glu298Glu as reference category, in men and women with T2DM.

From: The Asp298 allele of endothelial nitric oxide synthase is a risk factor for myocardial infarction among patients with type 2 diabetes mellitus

 

No MI

MI

   

Men

n = 156

(%)

n = 46

(%)

HR

95%CI

p

Patients with T2DM

Adjusted for differences in age:

Glu298Glu

89

79.5

23

20.5

1.00

  

Glu298Asp

57

76.0

18

24.0

1.13

0.61.2.09

0.705

Asp298Asp

10

66.7

5

33.3

2.54

0.95–6.79

0.064

Adjusted for differences in age, smoking, BMI, systolic blood pressure, HDL-cholesterol, serum triglycerides, and LTPA:

Glu298Glu

    

1.00

  

Glu298Asp

    

1.25

0.65–2.39

0.499

Asp298Asp

    

2.67

0.96–7.41

0.059

 

No MI

MI

   

Women

n = 162

(%)

n = 39

(%)

HR

95%CI

p

Patients with T2DM

Adjusted for differences in age:

Glu298Glu

90

81.8

20

18.2

1.00

  

Glu298Asp

64

82.1

14

17.9

0.92

0.46–1.84

0.808

Asp298Asp

8

61.5

5

38.5

2.97

1.11–7.95

0.030

Adjusted for differences in age, smoking, BMI, systolic blood pressure, HDL-cholesterol, serum triglycerides, and LTPA:

Glu298Glu

    

1.00

  

Glu298Asp

    

1.11

0.52–2.36

0.790

Asp298Asp

    

3.56

1.16–10.90

0.026

  1. Hazard ratios (HR) with 95% confidence intervals (955CI) were estimated using multivariate Cox proportional hazard models. BMI; body mass index. LTPA; leisure time physical activity.