A clinical and EEG scoring system that predicts early cortical response (N20) to somatosensory evoked potentials and outcome after cardiac arrest

Table 2 Results of univariate and multivariate analysis to define predictors of bilateral absence of early cortical responses to SSEPs (group 1) at day 1 and day 3.

n = 66	Univariate analysis			Multivariate analysis
	OR	95% CI*	p value	Beta**	OR	95% CI*	p-value
*Day-1*
Bilateral absence of corneal reflex	6.2	[2.0–19.0]	0.001	1.0	2.7	[0.7–11.0]	0.159
Bilateral absence of pupillary light reflex	9.3	[1.9–45.5]	0.006	-	-	-	-
Presence of myoclonus	22.5	[6.0–83.8]	<0.001	3.0	20.2	[4.8–84.7]	<0.001
Tonic-clonic seizure	1.2	[0.3–4.9]	0.794	-	-	-	-
Presence of malignant EEG	3.4	[0.8–14.4]	0.090	-	-	-	-
Extensor or absent motor responses to pain	5.4	[1.3–21.8]	0.017	1.7	5.6	[0.9–32.8]	0.055
*Day-3*
Bilateral absence of corneal reflex	9.9	[3.0–32.4]	<0.001	1.4	4.1	[0.8–20.9]	0.088
Bilateral absence of pupillary light reflex	21.7	[2.6–178.1]	0.004	2.1	7.8	[0.7–89.0]	0.097
Presence of myoclonus	7.9	[2.3–27.4]	0.001	2.5	11.7	[2.0–68.3]	0.006
Tonic-clonic seizure	0.2	[0.0–1.5]	0.108	-	-	-	-
Presence of malignant EEG	6.6	[1.9–23.2]	0.003	1.1	3.1	[0.6–16.2]	0.183
Extensor or absent motor responses to pain	22.6	[2.7–186.4]	0.004	2.8	17.3	[1.1–210.0]	0.025

* CI: Confidence Interval; ** Beta denotes the estimated coefficient in the multivariate logistic regression model which predicted poor SSEPs results. The score related to each item is calculated as follows: points = beta × 10, according to Sullivan et al. [25]

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