(A) Endothelin-1 contractions (after ET
receptor desensitisation) and (B) ET
receptor mRNA levels in cultured and non-cultured human internal mammary arteries, examined using in vitro pharmacology (n = 27) and real time PCR (n = 8) experiments. The results are shown as mean values ± S.E.M. Statistical analyses, comparing cultured with non-cultured, were performed using Student's t-test. There were no significant differences.