Table 5 Synergistic effect of AGT235 MM and AT1R CC genotypes and classical risk factors in CAD patients and controls

Hypertension

CAD

Controls

OR(95%CI)

CAD

Controls

OR(95%CI)

0

0

88

293

1

0

99

334

1

0

1

18

62

0.97(0.52–1.78)NS

1

7

21

1.12(0.42–2.89)NS

1

0

153

130

3.92(2.77–5.55)***

0

182

150

4.09(2.96–5.66)***

1

1

39

25

5.19(2.88–9.41)***

1

10

5

6.75(2.06–23.27)**

SI = 1.44; SIM = 1.36; RERI = 1.30; AP = 0.25

SI = 1.79; SIM = 1.47; RERI = 2.54; AP = 0.38

Smoking

0

0

145

315

1

0

177

356

1

0

1

37

58

1.39(0.86–2.24)NS

1

5

17

0.59(0.19–1.74)NS

1

0

96

108

1.93(1.36–2.75)**

0

104

128

1.63(1.18–2.27)**

1

1

20

29

1.50(0.79–2.85)NS

1

12

9

2.68(1.03–7.05)*

SI = 0.38; SIM = 0.56; RERI = -0.82; AP = -0.55

SI = 7.64; SIM = 2.79; RERI = 1.46; AP = 0.54

Obesity

0

0

172

352

1

0

201

394

1

0

1

42

65

1.32(0.84–2.07)NS

1

13

23

1.11(0.52–2.34)NS

1

0

69

71

1.99(1.34–2.95)**

0

80

90

1.74(1.22–2.50)**

1

1

15

22

1.40(0.67–2.89)NS

1

4

3

2.61(0.49–14.83)NS

SI = 0.31; SIM = 0.53; RERI = -0.91; AP = -0.65

SI = 1.89; SIM = 1.35; RERI = 0.76; AP = 0.29

Diabetes

0

0

171

396

1

0

201

450

1

0

1

41

80

1.19(0.77–1.84)NS

1

11

26

0.95(0.43–2.05)NS

1

0

70

27

6.00(3.63–9.98)***

0

80

34

5.27(3.34–8.33)***

1

1

16

7

5.29(2.00–14.47)***

1

6

0

--

SI = 0.83; SIM = 0.74; RERI = -0.90; AP = -0.17

--

Dyslipidaemia

0

0

73

370

1

0

82

424

1

0

1

14

80

0.89(0.45–1.71)NS

1

5

26

0.99(0.32–2.83)NS

1

0

168

53

16.07(10.59–24.43)***

0

199

60

17.15(11.62–25.37)***

1

1

43

7

31.14(12.81–79.15)***

1

12

0

--

SI = 2.01; SIM = 2.18; RERI = 15.18; AP = 0.49