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Table 5 Synergistic effect of AGT235 MM and AT1R CC genotypes and classical risk factors in CAD patients and controls

From: RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population

Classical risk factor AGT235 MM Whole population1 AT1R CC Whole population1
Hypertension   CAD Controls OR(95%CI)   CAD Controls OR(95%CI)
0 0 88 293 1 0 99 334 1
0 1 18 62 0.97(0.52–1.78)NS 1 7 21 1.12(0.42–2.89)NS
1 0 153 130 3.92(2.77–5.55)*** 0 182 150 4.09(2.96–5.66)***
1 1 39 25 5.19(2.88–9.41)*** 1 10 5 6.75(2.06–23.27)**
   SI = 1.44; SIM = 1.36; RERI = 1.30; AP = 0.25 SI = 1.79; SIM = 1.47; RERI = 2.54; AP = 0.38
Smoking         
0 0 145 315 1 0 177 356 1
0 1 37 58 1.39(0.86–2.24)NS 1 5 17 0.59(0.19–1.74)NS
1 0 96 108 1.93(1.36–2.75)** 0 104 128 1.63(1.18–2.27)**
1 1 20 29 1.50(0.79–2.85)NS 1 12 9 2.68(1.03–7.05)*
   SI = 0.38; SIM = 0.56; RERI = -0.82; AP = -0.55 SI = 7.64; SIM = 2.79; RERI = 1.46; AP = 0.54
Obesity         
0 0 172 352 1 0 201 394 1
0 1 42 65 1.32(0.84–2.07)NS 1 13 23 1.11(0.52–2.34)NS
1 0 69 71 1.99(1.34–2.95)** 0 80 90 1.74(1.22–2.50)**
1 1 15 22 1.40(0.67–2.89)NS 1 4 3 2.61(0.49–14.83)NS
   SI = 0.31; SIM = 0.53; RERI = -0.91; AP = -0.65 SI = 1.89; SIM = 1.35; RERI = 0.76; AP = 0.29
Diabetes         
0 0 171 396 1 0 201 450 1
0 1 41 80 1.19(0.77–1.84)NS 1 11 26 0.95(0.43–2.05)NS
1 0 70 27 6.00(3.63–9.98)*** 0 80 34 5.27(3.34–8.33)***
1 1 16 7 5.29(2.00–14.47)*** 1 6 0 --
   SI = 0.83; SIM = 0.74; RERI = -0.90; AP = -0.17 --
Dyslipidaemia         
0 0 73 370 1 0 82 424 1
0 1 14 80 0.89(0.45–1.71)NS 1 5 26 0.99(0.32–2.83)NS
1 0 168 53 16.07(10.59–24.43)*** 0 199 60 17.15(11.62–25.37)***
1 1 43 7 31.14(12.81–79.15)*** 1 12 0 --
   SI = 2.01; SIM = 2.18; RERI = 15.18; AP = 0.49 --
  1. SI, Rothman's synergy index for interaction; RERI, relative excess risk due to interaction; AP, proportion of disease attributable to interaction; *P < 0.05, **P < 0.005, ***P < 0.0001; 1We performed no further subdivision when analysing these polymorphisms because several classes resulted statistically impossible to analyse due to the reduced number of individuals there included.