RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population

Table 3 Allele, genotype and haplotype association between ACE polymorphism and CAD and RAS combined set of alleles association with CAD

	Whole population	Males	Females	≤ 45 subgroup
Allele
ACE11860 G	1.312(1.07–1.60)**	1.387(1.09–1.77)**	NS	NS
ACE I/D D	1.414(1.15–1.74)***	1.562(1.22–2.00)***	NS	NS
Genotype
ACE11860 GG	1.560(1.16–2.11)**	1.713(1.18–2.49)**	NS	NS
ACE I/D DD	1.795(1.34–2.41)***	2.283(1.57–3.31)***	NS	1.880(1.05–3.36)*
*ACE* haplotype ( *ACE* 11860/ *ACE* I/D)
A/I	0.670(0.54–0.83)***	0.660(0.51–0.85)**	0.653(0.43–1.00)*	NS
	CAD = 191, C = 425	CAD = 155, C = 251	CAD = 39, C = 175	CAD = 42, C = 179
A/D	1.526(1.03–2.27)*	NS	2.434(1.20–4.94)*	NS
	CAD = 47, C = 55	CAD = 35, C = 34	CAD = 14, C = 21	CAD = 8, C = 18
G/I	NS	NS	8.372 (2.13–32.87)**	NS
	CAD = 20, C = 23	CAD = 12, C = 21	CAD = 7, C = 3	CAD = 3, C = 6
G/D	1.256(1.03–1.53)*	1.440(1.13–1.84)**	NS	NS
	CAD = 335, C = 520	CAD = 269, C = 283	CAD = 66, C = 231	CAD = 75, C = 219
RAS combined set of alleles ¹ ( *ACE* 11860/ *ACE* I/D/ *AGT* 174/ *AGT* 235/ *AT1R* )
A/I/T/M/A	0.698(0.53–0.93)*	0.663(0.50–0.88)**	NS	NS
	CAD = 76, C = 179	CAD = 96, C = 164
A/I/T/T/A	0.727(0.55–0.97)*	NS	NS	NS
	CAD = 76, C = 173
A/D/M/T/A	NS	3.804(1.02–14.13)*	NS	NS
		CAD = 9, C = 3
A/I/M/T/C	0.324(0.11–0.95)*	NS	NS	NS
	CAD = 4, C = 20
G/D/T/T/A	1.459(1.06–2.02)*	1.400(1.01–1.95)*	NS	2.468(1.21–5.04)*
	CAD = 71, C = 88	CAD = 87, C = 82		CAD = 14, C = 20

Values presentation: OR(95% CI); *P < 0.05, **P < 0.005, ***P < 0.0001, NS not significant P > 0.05; CAD, number of CAD patients; C, number of control subjects.
¹Only combined set of alleles present in more than 10 individuals and yielding significant results are shown.

ISSN: 1471-2261