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Table 3 Allele, genotype and haplotype association between ACE polymorphism and CAD and RAS combined set of alleles association with CAD

From: RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population

  Whole population Males Females ≤ 45 subgroup
Allele     
ACE11860 G 1.312(1.07–1.60)** 1.387(1.09–1.77)** NS NS
ACE I/D D 1.414(1.15–1.74)*** 1.562(1.22–2.00)*** NS NS
Genotype     
ACE11860 GG 1.560(1.16–2.11)** 1.713(1.18–2.49)** NS NS
ACE I/D DD 1.795(1.34–2.41)*** 2.283(1.57–3.31)*** NS 1.880(1.05–3.36)*
ACE haplotype ( ACE 11860/ ACE I/D)
A/I 0.670(0.54–0.83)*** 0.660(0.51–0.85)** 0.653(0.43–1.00)* NS
  CAD = 191, C = 425 CAD = 155, C = 251 CAD = 39, C = 175 CAD = 42, C = 179
A/D 1.526(1.03–2.27)* NS 2.434(1.20–4.94)* NS
  CAD = 47, C = 55 CAD = 35, C = 34 CAD = 14, C = 21 CAD = 8, C = 18
G/I NS NS 8.372 (2.13–32.87)** NS
  CAD = 20, C = 23 CAD = 12, C = 21 CAD = 7, C = 3 CAD = 3, C = 6
G/D 1.256(1.03–1.53)* 1.440(1.13–1.84)** NS NS
  CAD = 335, C = 520 CAD = 269, C = 283 CAD = 66, C = 231 CAD = 75, C = 219
RAS combined set of alleles 1 ( ACE 11860/ ACE I/D/ AGT 174/ AGT 235/ AT1R )
A/I/T/M/A 0.698(0.53–0.93)* 0.663(0.50–0.88)** NS NS
  CAD = 76, C = 179 CAD = 96, C = 164   
A/I/T/T/A 0.727(0.55–0.97)* NS NS NS
  CAD = 76, C = 173    
A/D/M/T/A NS 3.804(1.02–14.13)* NS NS
   CAD = 9, C = 3   
A/I/M/T/C 0.324(0.11–0.95)* NS NS NS
  CAD = 4, C = 20    
G/D/T/T/A 1.459(1.06–2.02)* 1.400(1.01–1.95)* NS 2.468(1.21–5.04)*
  CAD = 71, C = 88 CAD = 87, C = 82   CAD = 14, C = 20
  1. Values presentation: OR(95% CI); *P < 0.05, **P < 0.005, ***P < 0.0001, NS not significant P > 0.05; CAD, number of CAD patients; C, number of control subjects.
  2. 1Only combined set of alleles present in more than 10 individuals and yielding significant results are shown.