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Table 3 Relationship between body mass index and acute myocardial infarction using three different methods to account for missing values (odds ratio, 95% confidence interval). The normal BMI category (18.0–24.9 kg/m2) was used as the reference group.

From: Lifestyle variables and the risk of myocardial infarction in the General Practice Research Database

Body mass index (kg/m2)

Case Deletion

Indicator Variable

Multiple Imputation (10 copies)

Crude Estimates of Effect

   

<18.0

1.23 (1.03–1.46)

1.21 (1.02–1.44)

1.03 (0.91–1.17)

18.0–24.9

Reference

Reference

Reference

25.0–29.9

1.21 (1.15–1.27)

1.21 (1.15–1.27)

1.20 (1.16–1.24)

≥30.0

1.35 (1.27–1.43)

1.35 (1.27–1.43)

1.40 (1.34–1.46)

Missing Indicator

n/a

0.96 (0.91–1.02)

n/a

Adjusted* Estimates of Effect

   

<18.0

1.15 (0.96–1.37)

1.13 (0.95–1.35)

1.00 (0.87–1.11)

18.0–24.9

Reference

Reference

Reference

25.0–29.9

1.18 (1.12–1.24)

1.18 (1.12–1.24)

1.16 (1.14–1.21)

≥30.0

1.35 (1.27–1.44)

1.35 (1.27–1.44)

1.41 (1.35–1.47)

Missing Indicator

n/a

1.13 (1.06–1.20)

n/a

  1. n/a: not applicable.
  2. * matched for age, GPRD practice and index date and adjusted for age, sex, heavy alcohol use, smoking and number of hospitalizations in the past year.