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Table 6 Odds ratios (95% Confidence Interval) of CAC > 0 or CAC ≥ 10 by MCP-1 tertile in African Americans

From: Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study

 

Tertiles of MCP-1

 

T1

T2

T3

p trend

Subjects

156

157

157

 

Range (pg/ml)

≤ 143.6

143.7 – 184.7

>184.7

 

Prevalence of CAC > 0, %

34.6

51.0

59.2

 

OR of CAC > 0

    

   No Adjustment

1.00

2.00 (1.21 3.32)

2.76 (1.71 4.48)

<0.0001

   Partial Adjustment*

1.00

1.16 (0.64 2.08)

1.25 (0.70 2.23)

0.44

   Multivariable Adjustment**

1.00

1.00 (0.53 1.88)

0.82 (0.44 1.54)

0.53

Prevalence of CAC ≥ 10, %

20.5

32.5

40.1

 

OR of CAC ≥ 10

    

   No Adjustment

1.00

2.02 (1.13 3.62)

2.78 (1.64 4.69)

0.0001

   Partial Adjustment*

1.00

1.03 (0.52 2.04)

1.11 (0.56 2.21)

0.75

   Multivariable Adjustment**

1.00

0.86 (0.41 1.82)

0.71 (0.34 1.47)

0.35

  1. CAC = coronary artery calcium score;
  2. * Adjusted for age and gender;
  3. ** Additionally adjusted for BMI, SBP, diabetes, HDL and LDL cholesterol, triglycerides, physical activity index, hours of TV watched/day, smoking status (current, former, never), pack-years of smoking, alcohol consumption, and hormone replacement therapy.