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Table 5 Odds ratios (95% confidence interval) of CAC > 0 or CAC ≥ 10 by MCP-1 quintile in whites

From: Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study

 

Quintiles of MCP-1

 

Q1

Q2

Q3

Q4

Q5

p trend

Subjects

449

449

450

449

449

 

Range (pg/ml)

≤ 142.1

142.2 – 167.8

167.9 – 193.7

193.8 – 230.3

> 230.3

 

Prevalence of CAC > 0, %

35.4

50.8

52.7

63.9

73.1

 

OR of CAC > 0

      

   No Adjustment

1.00

1.89 (1.45 2.47)

2.03 (1.57 2.62)

3.28 (2.53 4.25)

5.05 (3.81 6.69)

<0.0001

   Partial Adjustment*

1.00

1.26 (0.92 1.73)

0.99 (0.73 1.34)

1.42 (1.03 1.96)

2.00 (1.43 2.79)

<0.0001

   Multivariable Adjustment**

1.00

1.12 (0.79 1.61)

0.88 (0.63 1.22)

1.12 (0.79 1.59)

1.43 (1.00 2.03)

0.048

Prevalence of CAC ≥ 10, %

21.6

31.9

34.4

43.4

54.1

 

OR of CAC ≥ 10

      

   No Adjustment

1.00

1.71 (1.25 2.35)

1.93 (1.44 2.59)

2.84 (2.13 3.78)

4.45 (3.29 6.01)

<0.0001

   Partial Adjustment*

1.00

0.99 (0.66 1.47)

0.78 (0.54 1.14)

0.97 (0.66 1.42)

1.44 (0.97 2.14)

0.023

   Multivariable Adjustment**

1.00

0.84 (0.54 1.30)

0.73 (0.48 1.11)

0.85 (0.56 1.29)

1.15 (0.76 1.75)

0.19

  1. CAC = coronary artery calcium score;
  2. * Adjusted for age and gender;
  3. ** Additionally adjusted for field center, BMI, SBP, diabetes, HDL and LDL cholesterol, triglycerides, physical activity index, hours of TV watched/day, smoking status (current, former, never), pack-years of smoking, alcohol consumption, and hormone replacement therapy.