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Table 4 Odds ratios (95% Confidence Interval) of CAC > 0 or CAC ≥ 10 by sICAM-1 quintile in whites

From: Association of sICAM-1 and MCP-1 with coronary artery calcification in families enriched for coronary heart disease or hypertension: the NHLBI Family Heart Study

 

Quintiles of SICAM-1

 

Q1

Q2

Q3

Q4

Q5

p trend

Subjects

448

450

450

449

449

 

Range (ng/ml)

≤ 187.6

187.7 – 217.4

217.5 – 247.1

247.2 – 296.6

> 296.6

 

Prevalence of CAC > 0, %

47.3

53.1

53.8

58.8

62.8

 

OR of CAC > 0

      

   No Adjustment

1.00

1.27 (0.99 1.64)

1.29 (0.99 1.68)

1.59 (1.23 2.05)

1.83 (1.40 2.40)

<0.0001

   Partial Adjustment*

1.00

1.22 (0.91 1.63)

1.15 (0.84 1.58)

1.49 (1.09 2.05)

1.72 (1.26 2.36)

0.0005

   Multivariable Adjustment**

1.00

1.12 (0.82 1.54)

0.98 (0.70 1.36)

1.28 (0.91 1.80)

1.20 (0.86 1.69)

0.21

Prevalence of CAC ≥ 10, %

29.5

34.4

38.0

38.8

44.8

 

OR of CAC ≥ 10

      

No Adjustment

1.00

1.25 (0.94 1.66)

1.46 (1.11 1.92)

1.50 (1.15 1.96)

1.92 (1.47 2.50)

<0.0001

   Partial Adjustment*

1.00

1.13 (0.81 1.59)

1.36 (0.97 1.93)

1.31 (0.92 1.88)

1.88 (1.34 2.63)

0.0003

   Multivariable Adjustment**

1.00

1.06 (0.75 1.50)

1.19 (0.83 1.68)

1.10 (0.76 1.59)

1.34 (0.94 1.91)

0.13

  1. CAC = coronary artery calcium score;
  2. * Adjusted for age and gender;
  3. ** Additionally adjusted for field center, BMI, SBP, diabetes, HDL and LDL cholesterol, triglycerides, physical activity index, hours of TV watched/day, smoking status (current, former, never), pack-years of smoking, alcohol consumption, and hormone replacement therapy.