TY - JOUR AU - Parthasarathy, Hari K. AU - Alhashmi, Khamis AU - McMahon, Alex D. AU - Struthers, Allan D. AU - Connell, John MC AU - McInnes, Gordon T. AU - Ford, Ian AU - MacDonald, Thomas M. PY - 2007 DA - 2007/05/09 TI - Does the aldosterone: renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension? A clinical trial protocol for RENALDO (RENin-ALDOsterone) study JO - BMC Cardiovascular Disorders SP - 14 VL - 7 IS - 1 AB - High blood pressure is an important determinant of cardiovascular disease risk. Treated hypertensives do not attain a risk level equivalent to normotensives. This may be a consequence of suboptimal blood pressure control to which indiscriminate use of antihypertensive drugs may contribute. Indeed the recent ALLHAT[1]study suggests that thiazides should be given first to virtually all hypertensives. Whether this is correct or whether different antihypertensive therapies should be targeted towards different patients is a major unresolved issue, which we address in this study. SN - 1471-2261 UR - https://doi.org/10.1186/1471-2261-7-14 DO - 10.1186/1471-2261-7-14 ID - Parthasarathy2007 ER -