Potency, EC50 (-log M) a | ||||
---|---|---|---|---|
In Vivo Treatment | ACh | PETN | GTN | ISDN |
WT/EtOH | 6.97 ± 0.2 (n = 7) | n.d. | 6.98 ± 0.1 (n = 9) | 4.44 ± 0.1 (n = 4) |
WT/GTN | 7.05 ± 0.2 (n = 8) | n.d. | 6.44 ± 0.1 (n = 7)* | 4.55 ± 0.1 (n = 4) |
Mn-SOD+/-/EtOH | 7.16 ± 0.1 (n = 10) | n.d. | 6.68 ± 0.1 (n = 8) | 4.38 ± 0.1 (n = 4) |
Mn-SOD+/-/GTN | 6.86 ± 0.1 (n = 9) | n.d. | 5.77 ± 0.1 (n = 10)*# | 4.17 ± 0.1 (n = 4)* |
WT/DMSO | 6.89 ± 0.1 (n = 7) | 6.82 ± 0.3 (n = 6) | 5.64 ± 0.2 (n = 7) | n.d. |
WT/PETN | 7.26 ± 0.0 (n = 5)§ | 6.57 ± 0.2 (n = 6) | 5.97 ± 0.3 (n = 6) | n.d |
Mn-SOD+/-/DMSO | 7.12 ± 0.1 (n = 7) | 6.55 ± 0.2 (n = 7) | 5.70 ± 0.2 (n = 7) | n.d. |
Mn-SOD+/-/PETN | 7.30 ± 0.1 (n = 8)§ | 6.37 ± 0.1 (n = 8) | 5.71 ± 0.1 (n = 8) | n.d |