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Table 1 Vasodilator potency of ACh, GTN, PETN and ISDN in vessels from wild type or Mn-SOD+/- mice upon chronic treatment with GTN or PETN.

From: Mitochondrial oxidative stress and nitrate tolerance – comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD+/-mice

 

Potency, EC50 (-log M) a

In Vivo Treatment

ACh

PETN

GTN

ISDN

WT/EtOH

6.97 ± 0.2 (n = 7)

n.d.

6.98 ± 0.1 (n = 9)

4.44 ± 0.1 (n = 4)

WT/GTN

7.05 ± 0.2 (n = 8)

n.d.

6.44 ± 0.1 (n = 7)*

4.55 ± 0.1 (n = 4)

Mn-SOD+/-/EtOH

7.16 ± 0.1 (n = 10)

n.d.

6.68 ± 0.1 (n = 8)

4.38 ± 0.1 (n = 4)

Mn-SOD+/-/GTN

6.86 ± 0.1 (n = 9)

n.d.

5.77 ± 0.1 (n = 10)*#

4.17 ± 0.1 (n = 4)*

WT/DMSO

6.89 ± 0.1 (n = 7)

6.82 ± 0.3 (n = 6)

5.64 ± 0.2 (n = 7)

n.d.

WT/PETN

7.26 ± 0.0 (n = 5)§

6.57 ± 0.2 (n = 6)

5.97 ± 0.3 (n = 6)

n.d

Mn-SOD+/-/DMSO

7.12 ± 0.1 (n = 7)

6.55 ± 0.2 (n = 7)

5.70 ± 0.2 (n = 7)

n.d.

Mn-SOD+/-/PETN

7.30 ± 0.1 (n = 8)§

6.37 ± 0.1 (n = 8)

5.71 ± 0.1 (n = 8)

n.d

  1. a *, p < 0.05 vs. WT/EtOH and #, p < 0.05 vs. Mn-SOD+/-/EtOH.
  2. §, p < 0.05 vs. WT/DMSO and$, p < 0.05 vs. Mn-SOD+/-/DMSO.
  3. n.d. means not determined.