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Table 3 Parameter estimates from segregation analysis of residual LV mass values: Class D regressive models, conditional on proband phenotypes

From: Heritability and major gene effects on left ventricular mass in the Chinese population: a family study

Model Pure familial correlation, i.e. polygenic Pure major gene (Mendel) Mendel + familial correlation (mixed codominant) A Dominant, μAB = μAA A Recessive, i.e. B Dominant, μAB = μBB Unrestricted, general
  Parameter S.E. Parameter S.E. Parameter S.E. Parameter S.E. Parameter S.E. Parameter S.E.
qA [1]   0.098 0.028 0.093 0.030 0.040 0.020 0.000 0.142 0.109 0.024
τAA -   [1]   [1]   [1]   [1]   1.000 0.000
τAB -   [0.5]   [0.5]   [1]   [1]   0.249 0.100
τBB -   [0]   [0]   [0]   [0]   0.034 0.030
μAA 36.0 0.5 64.4 4.3 65.1 4.5 51.4 2.8 40.9 8.2 62.7 3.4
μAB = μAA   45.6 1.8 45.7 1.9 51.4 2.8 36.0 0.5 46.1 1.4
μBB = μAA   33.7 0.5 33.9 0.6 34.9 0.6 36.0 0.5 33.5 0.6
σ2 80.6 4.6 52.4 4.2 53.5 4.7 61.8 5.5 80.6 4.6 47.1 4.9
ρMF 0.199 0.072 0.327 0.093 0.315 0.091 0.246 0.079 0.199 0.072 0.334 0.098
ρMO 0.196 0.050 [0]   0.058 0.070 0.130 0.067 0.196 0.050 0.076 0.079
ρFO 0.093 0.059 [0]   -0.070 0.069 -0.025 0.064 0.093 0.059 -0.051 0.076
ρSS 0.118 0.055 [0]   0.000 0.000 0.037 0.069 0.118 0.055 0.017 0.065
# of 6   6   9   8   8   12  
parameters             
-2ln(L) 4721.80   4684.40   4682.38   4688.22   4721.80   4677.90  
AIC 4733.8   4696.4   4700.38   4704.22   4737.8   4701.9  
χ2 43.9   6.5   4.48   10.32   43.9    
P 0.000   0.370   0.214   0.035   0.000   Baseline  
  1. Abbreviation: qA, allele frequency; τAA, τAB, τBB, transmission probability; μAA, μAB, μBB, genotype means; σ2, variance; ρMF, ρMO, ρFO, ρSS, correlation coefficients among spouse, mother-offspring, father-ffspring and sibling pairs; #, number of parameters; ln(L), logarithm of likelihood; AIC, Akaike information criteria; P, p-value by compared with the unrestricted general model.