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Table 3 Parameter estimates from segregation analysis of residual LV mass values: Class D regressive models, conditional on proband phenotypes

From: Heritability and major gene effects on left ventricular mass in the Chinese population: a family study

Model

Pure familial correlation, i.e. polygenic

Pure major gene (Mendel)

Mendel + familial correlation (mixed codominant)

A Dominant, μAB = μAA

A Recessive, i.e. B Dominant, μAB = μBB

Unrestricted, general

 

Parameter

S.E.

Parameter

S.E.

Parameter

S.E.

Parameter

S.E.

Parameter

S.E.

Parameter

S.E.

qA

[1]

 

0.098

0.028

0.093

0.030

0.040

0.020

0.000

0.142

0.109

0.024

τAA

-

 

[1]

 

[1]

 

[1]

 

[1]

 

1.000

0.000

τAB

-

 

[0.5]

 

[0.5]

 

[1]

 

[1]

 

0.249

0.100

τBB

-

 

[0]

 

[0]

 

[0]

 

[0]

 

0.034

0.030

μAA

36.0

0.5

64.4

4.3

65.1

4.5

51.4

2.8

40.9

8.2

62.7

3.4

μAB

= μAA

 

45.6

1.8

45.7

1.9

51.4

2.8

36.0

0.5

46.1

1.4

μBB

= μAA

 

33.7

0.5

33.9

0.6

34.9

0.6

36.0

0.5

33.5

0.6

σ2

80.6

4.6

52.4

4.2

53.5

4.7

61.8

5.5

80.6

4.6

47.1

4.9

ρMF

0.199

0.072

0.327

0.093

0.315

0.091

0.246

0.079

0.199

0.072

0.334

0.098

ρMO

0.196

0.050

[0]

 

0.058

0.070

0.130

0.067

0.196

0.050

0.076

0.079

ρFO

0.093

0.059

[0]

 

-0.070

0.069

-0.025

0.064

0.093

0.059

-0.051

0.076

ρSS

0.118

0.055

[0]

 

0.000

0.000

0.037

0.069

0.118

0.055

0.017

0.065

# of

6

 

6

 

9

 

8

 

8

 

12

 

parameters

            

-2ln(L)

4721.80

 

4684.40

 

4682.38

 

4688.22

 

4721.80

 

4677.90

 

AIC

4733.8

 

4696.4

 

4700.38

 

4704.22

 

4737.8

 

4701.9

 

χ2

43.9

 

6.5

 

4.48

 

10.32

 

43.9

   

P

0.000

 

0.370

 

0.214

 

0.035

 

0.000

 

Baseline

 
  1. Abbreviation: qA, allele frequency; τAA, τAB, τBB, transmission probability; μAA, μAB, μBB, genotype means; σ2, variance; ρMF, ρMO, ρFO, ρSS, correlation coefficients among spouse, mother-offspring, father-ffspring and sibling pairs; #, number of parameters; ln(L), logarithm of likelihood; AIC, Akaike information criteria; P, p-value by compared with the unrestricted general model.