Figure 3
Characterizations of ACh-induced vasodilatation. (A) Changes in ACh-induced EDHF mediated vasodilatations on the 5-HT preconstricted rat mesenteric arteries after treated with DSP for 12 hours. The tests were performed in the presence of indomethacin (10-5 M) and L-NAME (10-4 M). (B) Changes in ACh-induced NO mediated vasodilatations on the 5-HT preconstricted rat mesenteric arteries after treated with DSP for 12 hours. The tests were done in the presence of indomethacin, charybdotoxin (5 × 10-8 M) and apamin (10-6 M). (C) Changes in ACh-induced PG mediated vasodilatations on the 5-HT preconstricted rat mesenteric arteries after treated with DSP for 12 hours. The tests were done in the presence of charybdotoxin, apamin and L-NAME. Each data points derived from 8 experiments and shown as mean ± S.E.M. *p < 0.05 and **p < 0.01 vs. control.