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Table 8 Overview of constitutively active ALK1 and TGF-β1 regulated gene expression in different endothelial cell types.

From: ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-β and constitutively active receptor induced gene expression

  ALK1QD regulated gene expression low TGF-β1 conc. (≤ 0.5 ng/ml) high TGF-β1 conc. (≥ 1 ng/ml)
Gene HMEC-1 HUVEC ECRF24 HMEC-1 HUVEC HMEC-1 HUVEC
GADD153 up up up down down down down
IL-8 up up up down down down down
SMAD6 up up up down - down up
COL5A1 up up - up up up down
HEF1 up - up up up up down
TLR4 up up - down - - down
ET-1 up up - up - up down
CARP up up - down - - -
HPTPη up - - - up - down
ID1 up up up down nt - nt
BMP6 up - - up nt up nt
ALK5 - down - - nt - nt
TβRII - - down down nt - nt
Endoglin up up - - nt - nt
c-myc - - - up down up down
ALK1 - - - - up - down
  1. up, up-regulated expression; down, down-regulated expression; -, unchanged expression; nt, not tested