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Table 8 Overview of constitutively active ALK1 and TGF-β1 regulated gene expression in different endothelial cell types.

From: ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-β and constitutively active receptor induced gene expression

 

ALK1QD regulated gene expression

low TGF-β1 conc. (≤ 0.5 ng/ml)

high TGF-β1 conc. (≥ 1 ng/ml)

Gene

HMEC-1

HUVEC

ECRF24

HMEC-1

HUVEC

HMEC-1

HUVEC

GADD153

up

up

up

down

down

down

down

IL-8

up

up

up

down

down

down

down

SMAD6

up

up

up

down

-

down

up

COL5A1

up

up

-

up

up

up

down

HEF1

up

-

up

up

up

up

down

TLR4

up

up

-

down

-

-

down

ET-1

up

up

-

up

-

up

down

CARP

up

up

-

down

-

-

-

HPTPη

up

-

-

-

up

-

down

ID1

up

up

up

down

nt

-

nt

BMP6

up

-

-

up

nt

up

nt

ALK5

-

down

-

-

nt

-

nt

TβRII

-

-

down

down

nt

-

nt

Endoglin

up

up

-

-

nt

-

nt

c-myc

-

-

-

up

down

up

down

ALK1

-

-

-

-

up

-

down

  1. up, up-regulated expression; down, down-regulated expression; -, unchanged expression; nt, not tested