Gene/Gene aliases [GenBank number] | ||||
---|---|---|---|---|
Transcription factors | Gene description | GeneChip™fold change (StdDev) | qRT-PCR RQ (RQMax/Min) | TGF-β regulated (Ref.) |
Inhibitor of DNA binding 1 (ID1) (represents [S78825]) | role in cell growth, senescence, and differentiation, involved in angiogenesis | 2.86 (0.71) | 6.56 (9.83/4.42) | [6, 70] |
Inhibitor of DNA binding 1B (ID1B) [S78825] | role in cell growth, senescence, and differentiation, involved in angiogenesis | 14* | nt | - |
Inhibitor of DNA binding 2 (ID2) [M97796] | role in cell growth and differentiation | 17.6* | nt | [70] |
Inhibitor of DNA binding 2B (ID2B) [M96843] | function unknown | 8.15* | nt | - |
Ankyrin repeat domain 1 (ANKRD1)/CARP [X83703] | endothelial and smooth muscle cell expression, angiogenic activity [71] | 4.46 (2.80) | 4.29 (13.70/2.41) | [41] |
High mobility group AT-hook 2 (HMGA2) [U28749] | HMG proteins are essential components of the enhancesome, may act as a transcriptional regulating factor | 6* | nt | - |
Signalling molecules | ||||
Interleukin 8 (IL-8) [M28130] | inflammatory response, angiogenic factor | 18.26 (10.83) | 1056.07 (1686.10/666.22) | [72-74] |
Endothelin (EDN1)/ET-1 [J05008] | vaso constrictor, involved in angiogenesis | 3.36 (0.30) | 3.87 (5.16/2.97) | [75] |
Chemokine (C-X-C motif) ligand 1 (CXCL1)/GROα1/MGSA [X54489] | immune response, tumor progression, angiogenic activity | 8.2* | nt | [70] |
Bone morphogenetic protein 6 (BMP6) [M60315] | induced by proinflammatory cytokines, involved in bone and cartilage development | 3.8* | 4.26 (5.60/3.30) | [70, 76] |
Heme oxygenase-1 (HO-1) [X06985] | heme catabolism, beneficial in cerebrovascular events, vasodilator | 3.8* | nt | [77] |
Jagged 1 (JAG1) [U73936] | ligand for notch 1, involved in angiogenesis | 3.9* | nt | [78] |
Parathyroid hormone-like hormone (PTHLH) [M24351] | involved in cell proliferation, apoptosis, cancer | 2.35* | nt | [79, 80] |
Signal transduction/regulation | ||||
SMAD6 [U59914] | inhibitor of TGF-β family member signaling 2 | 14.2 (9.41) | 14.56 (18.63/11.63) | [81] |
Toll-like receptor 4 (TLR4) [U93091] | LPS innate immune response | 4.33 (1.19) | 3.98 (5.51/2.92) | - |
Protein tyrosine phosphatase, receptor type, J (PTPRJ)/CD148/HPTPη [D37781] | involved in cell proliferation, differentiation, cell motility | 3.56 (1.58) | 2.08 (3.01/1.47) | - |
SMAD7 [AF010193] | inhibitor of TGF-β family member signaling 2 | 7.2* | nt | [81] |
Ras homolog gene family, member B (RHOB) [M12174] | role in endosomal trafficking [82] | 3.25* | nt | [70] |
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) [U67156] | activates c-Jun N-terminal kinase (JNK) | 3.2* | nt | - |
Endoglin (ENG)/CD105 (J05481) | TGF-β1, -β3 accessory receptor and signaling modulator | nd | 2.36 (3.08/1.84) | [83] |
Extracellular matrix | ||||
Collagen 5α1 (COL5A1) [D90279] | controls the initiation of collagen fibril assembly [62] | 7.13 (4.27) | 2.28 (2.93/1.81) | [59, 60] |
Serine (or cysteine) proteinase inhibitor 1 (SERPINH1)/HSP47 [D83174] | assists maturation of the ECM protein type I collagen | 2* | nt | [58] |
Stress response | ||||
DNA-damage-inducible transcript 3 (DDIT3)/ GADD153 [S40706] | transcription factor, associated with cell stress and apoptosis | 19.5 (2.60) | 4.55 (6.42/3.27) | - |
DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1) D85429] | linked to the 26S proteasome, up-regulated in bipolar disorder | 3.03 (1.00) | nt | - |
Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (HERPUD1) [D14695] | linked to the 26S proteasome, up-regulated by Wnt-1 | 4.1* | nt | - |
Cell adhesion and cytoskelet | ||||
Neural precursor cell expressed, developmentally down-regulated 9 (NEDD9)/ HEF1 [L43821] | actin filament bundle formation, cell adhesion, cytoskeleton organization and biogenesis, integrin mediated signalling pathway, regulation of cell cycle, regulation of cell growth, signal transduction | 5.8 (0.95) | 3.93 (5.74/2.73) | [84] |
Crystallin, alpha B (CRYAB) [S45630] | member of the small heat shock protein (HSP20) family, assists assembly of desmin filaments [85] | 11.1* | nt | [85, 86] |
Tropomyosin 1 (alpha) (TPM1), splice variant 2 | associated with the actin filaments | 2.3* | nt | [87, 88] |
Poliovirus receptor (PVR)/CD155 [M24407] | also involved in the regulation of cell adhesion and cell motility [89] | 2.35* | nt | - |
Solute carrier family 3, member 2 (SLC3A2)/CD98 [M21904] | activator of dibasic and neutral amino acid transport, mediates integrin signaling [90] | 2.5* | nt | - |
Miscellanous | ||||
Leukocyte receptor cluster (LRC) member 4 (LENG4) [S82470] | Over-expressed in bladder and breast carcinoma | 2.1* | nt | - |
Karyopherin alpha 3 (KPNA3) [Y12394] | nuclear transport protein 91a | 2.75* | nt | - |
Ankyrin repeat domain 15 (ANKRD15) [D79994] | plays a role in cell growth | 2.3* | nt | - |
Squalene epoxidase (SQLE) [D78129)] | catalyzes the first oxygenation step in sterol biosynthesis | 2.45* | nt | - |