BMC Cardiovascular Disorders

Table 3 Number of molecules of cholesteryl ester (CE), LDL diameter and LCAT and CETP activities of guinea pigs fed a control diet, low dose MTPi (LDI), high dose MTPi (HDI) or atorvastatin.

From: JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

Diets	CE molecules	LDL diameter	LCAT	CETP
		nanometers	(pmol/min.mg)
Control (n = 10)	1993 ± 422^a	16.47 ± 3.63^a	19.6 ± 11.0^a	36.1 ± 12.5^a
LDI (n= 10)	2072 ± 536^a	16.67 ± 3.05^a	14.4 ± 6.4^a	31.0 ± 21.1^a
HDI (n = 9)	2026 ± 132.5^a	16.58 ± 7.85^a	14.6 ± 8.5^a	19.4 ± 13.0^ab
Atorvastatin (n = 9)	1080 ± 1092^b	11.52 ± 2.69^b	13.4 ± 10.9^a	12.8 ± 4.2^b

¹Data are presented as mean ± SD for the number of guinea pigs indicated in parenthesis. Numbers in a column with different superscripts are considered significantly different (P < 0.01) as determined by one way ANOVA and LSD as post hoc test.

Back to article page

ISSN: 1471-2261

Contact us

Submission enquiries: bmccardiovasculardisorders@biomedcentral.com
General enquiries: ORSupport@springernature.com