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Table 2 Plasma total cholesterol (TC), triglycerides (TG), VLDL-C, LDL-C and HDL-C of guinea pigs fed a control diet, low dose MTPi (LDI), high dose MTPi (HDI) or atorvastatin

From: JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

Diets

TC

TG

VLDL-C

LDL-C

HDL-C

   

(mg/dL)

  

Control (10)

146.9 ± 42.2a

135.8 ± 118.9a

8.1 ± 5.5ab

123.9 ± 43.5a

13.6 ± 4.5a

LDI (10)

116.9 ± 29.7b

66.7 ± 29.6b

3.7 ± 3.0a

93.3 ± 26.2b

18.5 ± 8.0a

HDI (9)

116.1 ± 23.3b

74.3 ± 31.7b

9.0 ± 8.6b

90.5 ± 28.8b

15.6 ± 7.1a

Atorvastatin (9)

76.5 ± 29.8c

49.4 ± 32.2c

2.9 ± 2.6a

59.4 ± 29.3c

14.1 ± 5.6a

  1. 1Data are presented as mean ± SD for the number of guinea pigs indicated in parenthesis. Numbers in a column with different superscripts are considered significantly different (P < 0.01) as determined by one way ANOVA and LSD as a post-hoc test
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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