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Table 1 Composition of Control, low dose of the inhibitor (LDI), high dose of the inhibitor (HDI) and atorvastatin diets

From: JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

Components

Control %

LDI %

HDI %

Atorvastatin %

Soybean protein

22.5

22.5

22.5

22.5

Methionine

0.5

0.5

0.5

0.5

Sucrose

25

25

25

25

Corn Starch

15

15

15

15

Fat mix1

15.1

15.1

15.1

15.1

Cellulose

10

10

10

10

Guar gum

2.5

2.5

2.5

2.5

Mineral Mix2

8.2

8.2

8.2

8.2

Vitamin Mix2

1.1

1.1

1.1

1.1

Cholesterol

0.08

0.08

0.08

0.08

JTT-130

0

0.0005

0.0015

0

Statin

0

0

0

0.05

  1. 1 Fat mix for the diet contains olive oil-palm kernel oil-safflower oil (1:2:1.8), high in lauric and myristic acids.
  2. 2 Mineral and vitamin mix adjusted to meet NRC requirements for guinea pigs. Detailed composition of the vitamin and mineral mix has been reported elsewhere (Fernandez et al. 1992b).
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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