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Figure 3 | BMC Cardiovascular Disorders

Figure 3

From: Sirolimus increases tissue factor expression but not activity in cultured human vascular smooth muscle cells

Figure 3

Sirolimus does not stimulate TF release and activity from SMC. Human SMC released much higher TF activity into the culture medium than endothelial cells (HUVECs) (p < 0.0001, n = 6–9). TF activity released from SMC was not further increased by sirolimus (20 ng/ml, 24 hours). The TF activity released from HUVECs was significantly stimulated by TNF-α (20 ng/ml; 5 hours, p < 0.05, n = 9).

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