Figure 3From: Sirolimus increases tissue factor expression but not activity in cultured human vascular smooth muscle cells Sirolimus does not stimulate TF release and activity from SMC. Human SMC released much higher TF activity into the culture medium than endothelial cells (HUVECs) (p < 0.0001, n = 6–9). TF activity released from SMC was not further increased by sirolimus (20 ng/ml, 24 hours). The TF activity released from HUVECs was significantly stimulated by TNF-α (20 ng/ml; 5 hours, p < 0.05, n = 9).Back to article page