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Table 3 Summary of drug dose and treatment regimens

From: Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials

Study Aprotinin TXA EACA
Isetta et al. [25] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
L = 15 mg/kg NS
  L = 0.5 × 106
M = 0.5 × 106
  
Blauhut et al. [27] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 1.0 × 106 KIU
L = 10 mg/kg
M = 1.0 mg/kg/h
NS
Penta de Peppo et al. [20] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
L = 10 mg/kg M = 1.0 mg/kg/h L = 10 g
M = 2.0 g/h for 5 h
Corbeau et al. [23] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
L = 15 mg/kg
E = 15 mg/kg
NS
Pugh et al. [22] L = 1.0 × 106 KIU
P = 1.0 × 106 KIU
L = 2.5 g
P = 2.5 g
NS
Speekenbrink et al. [21] P = 2.0 × 106 KIU L = 10 mg/kg
M = 1.0 mg/kg/h
NS
Menichetti et al. [24] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
L = 10 mg/kg
M = 3.0 mg/kg/h
P = 10 mg/kg
L = 80 mg
M= 30 mg/kg/h
P = 80 mg/kg
Pinosky et al. [33] NS L = 15 mg/kg
M = 1.0 mg/kg/h for 6 h
L = 150 mg/kg
M = 10 mg/kg/h for 6 h
Mongan et al. [31] L = 2.0 x 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
L = 15 mg/kg
M = 2.0 mg/kg/h for 6 h
NS
Hardy et al. [26] NS L = 10 g L = 15 g
M = 1.0 g/h
Eberl et al. [29] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
NS L = 10 g
M = 2.5 g/h
P = 10 g
Misfeld et al. [30] P = 1.0 × 106 KIU
E = 0.2 × 106 KIU/h for 5 h
L = 10 mg/kg
M = 1.0 mg/kg/h
NS
Casati et al. [28] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
L = 1.0 g
M = 400 mg/h
P = 500 mg
L = 5.0 g
M = 2.0 g/h
P = 2.5 g
Bernet et al. [34] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
L = 10 g NS
Nuttall et al. [32] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
L = 10 mg/kg
M = 1.0 mg/kg/h
NS
Maineri et al. [38] NS L = 20 mg/kg
M = 2.0 mg/kg/h
L = 10 g
M = 2.0 g/h
Wong et al. [37] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
L = 10 g NS
Casati et al. [35] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
L = 1.0 g
M = 400 mg/h
P = 500 mg
NS
Greilich et al. [36] L = 2.0 × 106 KIU
M = 0.5 × 106 KIU/h
P = 2.0 × 106 KIU
NS L = 100 mg/kg
M = 2.5 mg/kg/h
P = 5.0 g
Ray et al. [6] L = 1.0 × 106 KIU
P = 1.0 × 106 KIU
NS L = 5.0 g
M = 1.25 g/h
P = 5.0 g
  1. L = loading dose, M = maintenance dose/continuous infusion, P = pump prime dose, E = after protamine administration, KIU = kallikrein inhibitor units, NS = not studied, mg = milligram, g = gram, kg = kilogram, h = hour