Table 3 Summary of drug dose and treatment regimens
Study | Aprotinin | TXA | EACA |
|---|---|---|---|
Isetta et al. [25] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | L = 15 mg/kg | NS |
|  | L = 0.5 × 106 M = 0.5 × 106 |  |  |
Blauhut et al. [27] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 1.0 × 106 KIU | L = 10 mg/kg M = 1.0 mg/kg/h | NS |
Penta de Peppo et al. [20] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | L = 10 mg/kg M = 1.0 mg/kg/h | L = 10 g M = 2.0 g/h for 5 h |
Corbeau et al. [23] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | L = 15 mg/kg E = 15 mg/kg | NS |
Pugh et al. [22] | L = 1.0 × 106 KIU P = 1.0 × 106 KIU | L = 2.5 g P = 2.5 g | NS |
Speekenbrink et al. [21] | P = 2.0 × 106 KIU | L = 10 mg/kg M = 1.0 mg/kg/h | NS |
Menichetti et al. [24] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | L = 10 mg/kg M = 3.0 mg/kg/h P = 10 mg/kg | L = 80 mg M= 30 mg/kg/h P = 80 mg/kg |
Pinosky et al. [33] | NS | L = 15 mg/kg M = 1.0 mg/kg/h for 6 h | L = 150 mg/kg M = 10 mg/kg/h for 6 h |
Mongan et al. [31] | L = 2.0 x 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | L = 15 mg/kg M = 2.0 mg/kg/h for 6 h | NS |
Hardy et al. [26] | NS | L = 10 g | L = 15 g M = 1.0 g/h |
Eberl et al. [29] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | NS | L = 10 g M = 2.5 g/h P = 10 g |
Misfeld et al. [30] | P = 1.0 × 106 KIU E = 0.2 × 106 KIU/h for 5 h | L = 10 mg/kg M = 1.0 mg/kg/h | NS |
Casati et al. [28] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | L = 1.0 g M = 400 mg/h P = 500 mg | L = 5.0 g M = 2.0 g/h P = 2.5 g |
Bernet et al. [34] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | L = 10 g | NS |
Nuttall et al. [32] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | L = 10 mg/kg M = 1.0 mg/kg/h | NS |
Maineri et al. [38] | NS | L = 20 mg/kg M = 2.0 mg/kg/h | L = 10 g M = 2.0 g/h |
Wong et al. [37] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | L = 10 g | NS |
Casati et al. [35] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | L = 1.0 g M = 400 mg/h P = 500 mg | NS |
Greilich et al. [36] | L = 2.0 × 106 KIU M = 0.5 × 106 KIU/h P = 2.0 × 106 KIU | NS | L = 100 mg/kg M = 2.5 mg/kg/h P = 5.0 g |
Ray et al. [6] | L = 1.0 × 106 KIU P = 1.0 × 106 KIU | NS | L = 5.0 g M = 1.25 g/h P = 5.0 g |