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Table 5 Estimated incidence rates and relative risks for mild or greater AR. The number of expected cases were based on estimated incidence rates utilizing the pooled control (unexposed) groups of these studies. Relative risks and z statistics were calculated within each study.

From: Risk of valvular heart disease associated with use of fenfluramine

Author, year Duration (months) "Incident" cases Expected cases p-value by Poisson Relative Risk (RR) Lower 95% CI of RR Upper 95% CI of RR z p-value
Khan, 1998 26.5 38.9 1.939 <0.00001 59.5 31.6 112.1 12.7 <0.00001
  4.9 3.5 0.086 <0.00001 69.1 31.1 153.4 10.4 <0.00001
  9.0 5.6 0.125 <0.00001 108.0 57.1 204.4 14.4 <0.00001
Weissman, 1998 2.4 11.6 0.696 <0.00001 15.3 8.4 27.9 8.9 <0.00001
Shively, 1999 6.9 9.3 0.685 <0.00001 38.4 18.9 78.0 10.1 <0.00001
Hensrud, 1999 9.6 3.3 0.075 <0.00001 7.8 1.2 51.8 2.1 0.016
Ryan, 1999 16.7 13 0.600 <0.00001 - - - - -
Gardin, 2000 2.0 0.03 0.042 0.96 0.7 0.0 61295 -0.1 0.52
  4.5 10.3 0.226 <0.00001 47.8 31.3 73.0 17.9 <0.00001
  9.0 8.2 0.459 <0.00001 18.8 10.6 33.3 10.0 <0.00001
  15.0 10.5 0.563 <0.00001 19.5 11.6 32.9 11.2 <0.00001
  22.0 14.5 0.816 <0.00001 18.7 11.6 30.0 12.1 <0.00001
  2.0 0 0.080 0.92 0.0 0.0 - -0.3 0.60
  4.5 7.5 0.359 <0.00001 26.1 15.0 45.2 11.6 <0.00001
  9.0 16.2 0.652 <0.00001 31.0 20.6 46.7 16.5 <0.00001
  15.0 2.8 0.190 0.0010 18.5 7.6 45.1 6.4 <0.00001
Jollis, 2000 2.0 0.10 0.022 0.022 5.1 0.0 1233 0.6 0.28
  4.5 2.8 0.618 0.026 4.8 1.6 14.9 2.8 0.0029
  9.0 14.1 1.638 <0.00001 9.3 5.4 15.9 8.1 <0.00001
  18.0 31.7 2.486 <0.00001 13.8 9.2 20.6 12.7 <0.00001
  30.0 11.9 1.131 <0.00001 11.4 6.6 19.7 8.7 <0.00001
Davidoff, 2001 2.5 5.0 0.300 <0.00001 20.8 9.9 43.4 8.1 <0.00001
Summary, 2002 8.78 220.8 14.01 <0.00001 19.6 16.3 23.5 31.7 <0.00001