Table 5 Estimated incidence rates and relative risks for mild or greater AR. The number of expected cases were based on estimated incidence rates utilizing the pooled control (unexposed) groups of these studies. Relative risks and z statistics were calculated within each study.

26.5

38.9

1.939

<0.00001

59.5

31.6

112.1

12.7

<0.00001

4.9

3.5

0.086

<0.00001

69.1

31.1

153.4

10.4

<0.00001

9.0

5.6

0.125

<0.00001

108.0

57.1

204.4

14.4

<0.00001

2.4

11.6

0.696

<0.00001

15.3

8.4

27.9

8.9

<0.00001

6.9

9.3

0.685

<0.00001

38.4

18.9

78.0

10.1

<0.00001

9.6

3.3

0.075

<0.00001

7.8

1.2

51.8

2.1

0.016

16.7

13

0.600

<0.00001

-

-

-

-

-

2.0

0.03

0.042

0.96

0.7

0.0

61295

-0.1

0.52

4.5

10.3

0.226

<0.00001

47.8

31.3

73.0

17.9

<0.00001

9.0

8.2

0.459

<0.00001

18.8

10.6

33.3

10.0

<0.00001

15.0

10.5

0.563

<0.00001

19.5

11.6

32.9

11.2

<0.00001

22.0

14.5

0.816

<0.00001

18.7

11.6

30.0

12.1

<0.00001

2.0

0

0.080

0.92

0.0

0.0

-

-0.3

0.60

4.5

7.5

0.359

<0.00001

26.1

15.0

45.2

11.6

<0.00001

9.0

16.2

0.652

<0.00001

31.0

20.6

46.7

16.5

<0.00001

15.0

2.8

0.190

0.0010

18.5

7.6

45.1

6.4

<0.00001

2.0

0.10

0.022

0.022

5.1

0.0

1233

0.6

0.28

4.5

2.8

0.618

0.026

4.8

1.6

14.9

2.8

0.0029

9.0

14.1

1.638

<0.00001

9.3

5.4

15.9

8.1

<0.00001

18.0

31.7

2.486

<0.00001

13.8

9.2

20.6

12.7

<0.00001

30.0

11.9

1.131

<0.00001

11.4

6.6

19.7

8.7

<0.00001

2.5

5.0

0.300

<0.00001

20.8

9.9

43.4

8.1

<0.00001

8.78

220.8

14.01

<0.00001

19.6

16.3

23.5

31.7

<0.00001