Skip to main content

Table 4 Raw data for mitral regurgitation (moderate or greater). When duration of exposure was reported as a range, the midpoint of the range is given here. "Time off" refers to the time between the last dose of anorexic and the echocardiogram.

From: Risk of valvular heart disease associated with use of fenfluramine

Author, year

Mean Age

Fen dose (mg/day)

Dexfen dose (mg/day)

Duration (months)

Time off (months)

Controls (N)

Affected in Controls

Exposed (N)

Affected in Exposed

Khan, 1998

45.3

90

30

20.6

3.9

233

0

233

2

Weissman, 1998

45.1

0

30

2.4

1.3

333

4

677

12

Shively, 1999

50.0

0

30

6.9

8.5

189

1

223

3

Hensrud, 1999

42.0

40

0

9.6

1.5

11

0

19

0

Ryan, 1999

49.1

60

30

16.7

12.2

0

0

79

1

Gardin, 2000

46.9

46

0

11.9

6.8

537

17

452

23

Gardin, 2000

48.4

0

29

6

5.3

  

472

23

Jollis, 2000

46.1

60

0

2

15

668

10

25

0

 

46.1

60

0

4.5

15

  

313

7

 

46.1

60

0

9

15

  

412

12

 

46.1

60

0

18

15

  

315

8

 

46.1

60

0

30

15

  

86

2

Davidoff, 2001

48.8

60

0

2.5

53

254

12

276

14