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Table 4 Raw data for mitral regurgitation (moderate or greater). When duration of exposure was reported as a range, the midpoint of the range is given here. "Time off" refers to the time between the last dose of anorexic and the echocardiogram.

From: Risk of valvular heart disease associated with use of fenfluramine

Author, year Mean Age Fen dose (mg/day) Dexfen dose (mg/day) Duration (months) Time off (months) Controls (N) Affected in Controls Exposed (N) Affected in Exposed
Khan, 1998 45.3 90 30 20.6 3.9 233 0 233 2
Weissman, 1998 45.1 0 30 2.4 1.3 333 4 677 12
Shively, 1999 50.0 0 30 6.9 8.5 189 1 223 3
Hensrud, 1999 42.0 40 0 9.6 1.5 11 0 19 0
Ryan, 1999 49.1 60 30 16.7 12.2 0 0 79 1
Gardin, 2000 46.9 46 0 11.9 6.8 537 17 452 23
Gardin, 2000 48.4 0 29 6 5.3    472 23
Jollis, 2000 46.1 60 0 2 15 668 10 25 0
  46.1 60 0 4.5 15    313 7
  46.1 60 0 9 15    412 12
  46.1 60 0 18 15    315 8
  46.1 60 0 30 15    86 2
Davidoff, 2001 48.8 60 0 2.5 53 254 12 276 14