Table 3 Raw data for aortic regurgitation (mild or greater). When duration of exposure was reported as a range, the midpoint of the range is given here. "Time off" refers to the time between the last dose of anorexic and the echocardiogram.
From: Risk of valvular heart disease associated with use of fenfluramine
Author, year | Mean Age | Fen dose (mg/day) | Dexfen dose (mg/day) | Duration (months) | Time off (months) | Controls (N) | Affected in Controls | Exposed (N) | Affected in Exposed |
|---|---|---|---|---|---|---|---|---|---|
Khan, 1998 | 46.0 | 90 | 0 | 26.5 | 3.9 | 233 | 3 | 163 | 41 |
43.0 | 0 | 30 | 4.9 | 3.9 | 39 | 4 | |||
44.7 | 0 | 30 | 9.0 | 3.9 | 31 | 6 | |||
Weissman, 1998 | 45.1 | 0 | 30 | 2.4 | 1.3 | 330 | 12 | 671 | 36 |
Shively, 1999 | 50.0 | 0 | 30 | 6.9 | 8.5 | 189 | 4 | 223 | 14 |
Hensrud, 1999 | 42.0 | 40 | 0 | 9.6 | 1.5 | 11 | 1 | 19 | 5 |
Ryan, 1999 | 49.1 | 60 | 30 | 16.7 | 12.2 | 0 | 0 | 79 | 13 |
Gardin, 2000 | 46.9 | 46 | 0 | 2.0 | 6.8 | 536 | 22 | 48 | 2 |
46.9 | 46 | 0 | 4.5 | 6.8 | 115 | 15 | |||
46.9 | 46 | 0 | 9.0 | 6.8 | 117 | 13 | |||
46.9 | 46 | 0 | 15.0 | 6.8 | 86 | 14 | |||
46.9 | 46 | 0 | 22.0 | 6.8 | 85 | 18 | |||
48.4 | 0 | 29 | 2.0 | 5.3 | 92 | 0 | |||
48.4 | 0 | 29 | 4.5 | 5.3 | 183 | 15 | |||
48.4 | 0 | 29 | 9.0 | 5.3 | 166 | 23 | |||
48.4 | 0 | 29 | 15.0 | 5.3 | 29 | 4 | |||
Jollis, 2000 | 46.1 | 60 | 0 | 2.0 | 15 | 669 | 24 | 25 | 1 |
46.1 | 60 | 0 | 4.5 | 15 | 313 | 14 | |||
46.1 | 60 | 0 | 9.0 | 15 | 415 | 29 | |||
46.1 | 60 | 0 | 18.0 | 15 | 315 | 43 | |||
46.1 | 60 | 0 | 30.0 | 15 | 86 | 15 | |||
Davidoff, 2001 | 48.8 | 60 | 0 | 2.5 | 53 | 254 | 11 | 276 | 17 |