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Table 3 Raw data for aortic regurgitation (mild or greater). When duration of exposure was reported as a range, the midpoint of the range is given here. "Time off" refers to the time between the last dose of anorexic and the echocardiogram.

From: Risk of valvular heart disease associated with use of fenfluramine

Author, year Mean Age Fen dose (mg/day) Dexfen dose (mg/day) Duration (months) Time off (months) Controls (N) Affected in Controls Exposed (N) Affected in Exposed
Khan, 1998 46.0 90 0 26.5 3.9 233 3 163 41
  43.0 0 30 4.9 3.9    39 4
  44.7 0 30 9.0 3.9    31 6
Weissman, 1998 45.1 0 30 2.4 1.3 330 12 671 36
Shively, 1999 50.0 0 30 6.9 8.5 189 4 223 14
Hensrud, 1999 42.0 40 0 9.6 1.5 11 1 19 5
Ryan, 1999 49.1 60 30 16.7 12.2 0 0 79 13
Gardin, 2000 46.9 46 0 2.0 6.8 536 22 48 2
  46.9 46 0 4.5 6.8    115 15
  46.9 46 0 9.0 6.8    117 13
  46.9 46 0 15.0 6.8    86 14
  46.9 46 0 22.0 6.8    85 18
  48.4 0 29 2.0 5.3    92 0
  48.4 0 29 4.5 5.3    183 15
  48.4 0 29 9.0 5.3    166 23
  48.4 0 29 15.0 5.3    29 4
Jollis, 2000 46.1 60 0 2.0 15 669 24 25 1
  46.1 60 0 4.5 15    313 14
  46.1 60 0 9.0 15    415 29
  46.1 60 0 18.0 15    315 43
  46.1 60 0 30.0 15    86 15
Davidoff, 2001 48.8 60 0 2.5 53 254 11 276 17