The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats

Table 4 Polymorphic changes at the STSL locus identified in different rat strains

Gene	Position	Nucleotide change^a	Effect^b	Wistar	WKA	WKY	SHR	SHRSP	GH
*Abcg5*	5'-UTR	-99A>G	-	±√
	Intron1	IVS1-8delC	-		√	√	√	√	√
		IVS1-95 A>C	-		√	√	√	√	√
		IVS1-258 A>G	-		√	√	√	√	√
	Intron3	IVS3+14 T>C	-		√	√	√	√
	Intron4	IVS4+86 T>C	-		√	√	√	√
	Intron5	IVS5+70 A>G	-	√	√				√
		IVS5-90 C>T	-		√	√	√	√
	Intron6	IVS6+64 C>T	-			√	√	√
	Exon7	856 C>T	G283G			√	√	√
	Exon8	1061 C>T	L352L	±√	√	√	√	√	√
	Intron8	IVS8+10 delC	-		√	√	√	√
		IVS8-171 C>T	-						√
	Exon9	1265 C>T	R420R	√	√	√	√	√	√
		1288 T>C	L427L			√	√	√	√
	Intron10	IVS10+60A>G	-		√	√	√	√	√
		IVS10+97 G>C	-		√	√	√	√	√
		IVS10+99 G>T	-						√
	Intron11	IVS11+24 T>G	-				√	√
		IVS11+33 delG	-				√	√
	Exon 12	1754 G>T	G583C			√	√	√
	3'-UTR	*251 T>C	-	±√
		*261 C>T	-	±√
		*353 C>A	-	±√	√	√	√	√
*Abcg8*	Intron 1	IVS1+399 A>C	-	±√	√	√	√	√
		IVS1+558 C>A	-			√	√	√
		IVS1-53 A>G	-	±√	√	√	√	√	√
	Intron 6	IVS6-34 G>A	-			√	√	√
	Intron 9	IVS9+13 C>T	-	±√		√	√	√	√
		IVS9+75 C>T	-		√
	3'-UTR	*101 C>T	-	±√		√	√	√
		*1461 A>G	-	±√		√	√	√
		*1458 T>C	-	±√		√	√	√	√
		*1777_1778insAGG	-			√	√	√
		*1781 T>G	-			√	√	√	√
		*1799 A>G	-	±√		√	√	√
		*1967 G>T	-	±√		√	√	√
		*2099_2100ins143 nt	-	±√		√	√	√	√

±√ indicates for heterozygous, √ for homozygous ^a Numbering based as indicated in Table 1, see Additional file 1 ^b Numbering based upon the first ATG as +1 All sequences are same as that of Sprague Dawley, unless indicated by the check mark. Sequence in bold indicates the coding change.

ISSN: 1471-2261