Figure 1

Organisation of the rat Abcg5 and Abcg8 genes The top line indicates the restriction endonuclease map of the STSL locus; B, Bam HI; E, EcoRI; S, Sal I, X, XbaI. The second line indicates Abcg5 and Abcg8 gene organisation, with the vertical lines representing exons, numbered as shown. The 379 bp separating 5'ends of Abcg5 and Abcg8 is indicated. The direction of transcription of Abcg5 and Abcg8 is as indicated by the arrows, resulting in mRNAs indicated on the line below. The gray portions indicate the UTRs for Abcg5 and Abcg8. The polypeptides are depicted with the predicted transmembrane spanning regions, as well as the A, B and C Walker motifs, characteristic for the ABC family of protein.