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Table 2 Effect of treatment on body temperature (in °C) and outcome. Effects on area under the curve measurements were adjusted for body temperature at start of treatment.

From: Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]

  Acetaminophen N = 25 Ibuprofen N = 24 Placebo N = 25
Temperature at 24 hrs (mean, SD) 37.2 (0.5) 37.2 (0.4) 37.2 (0.5)
   Difference with placebo (95% CI) 0 (-.3 to 0.3) 0 (-.3 to 0.3) -
Change in temperature at 24 hrs, (mean, SD) -0.1 (0.6) 0.1 (0.6) 0.2 (0.5)
   Difference with placebo (95% CI) 0.3 (0 to 0.6) 0.1 (-.3 to 0.4) -
Change in temperature after 5 days in(SD) 0.3 (1.2) 0.6 (1.6) 0.1 (0.6)
   Difference with placebo (95% CI) -.2 (-1.0 to 0.7) -.5 (-1.2 to 0.2) -
Area under the curve (first 24 hours) in hrs × °C (SD) 888 (12) 883 (16) 893 (14)
   Difference with placebo (95% CI) 7 (0 to 12) 7 (2 to 12)) -
Area under the curve (5 days) in hrs × °C (SD) 4443 (63) 4367 (128) 4438 (64)
   Difference with placebo (95% CI) 9 (-52 to 34) 23 (-15 to 62) -
N of patients with Modified Rankin score >2, (%) 13 (52%) 9 (38%) 12 (48%)
N of patients with Barthel index <20 (%) 14 (56%) 10 (42%) 14 (56%)