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Table 3 Ratios of serum cholesterol precursors and plant sterols to total cholesterol (10-2mg/mg of cholesterol) during the study.

From: Short-term LDL cholesterol-lowering efficacy of plant stanol esters

  Experimental period Follow-up period   
  0 day 4 days 8 days 15 days 17 or 18 days 22 days P1 P2
Squalene/TC 0.49 ± 0.12 0.46 ± 0.14 0.55 ± 0.20 0.51± 0.12 0.46 ± 0.14 0.48 ± 0.20 0.390 0.662
Δ8-cholestenol/TC 0.22 ± 0.09 0.22 ± 0.09 0.24 ± 0.06 0.25 ± 0.08 0.24 ± 0.07 0.23 ± 0.07 0.101 0.280
Δ7-lathosterol/TC 1.67 ± 0.58 1.75 ± 0.60 1.89 ± 0.34 1.98 ± 0.48a 1.86 ± 0.46 1.71 ± 0.45 0.012 0.116
Desmosterol/TC 1.05 ± 0.26 1.01 ± 0.18 1.09 ± 0.15 1.13 ± 0.14 1.04 ± 0.15b 1.06 ± 0.13 0.026 0.018
Campesterol/TC 2.86 ± 0.89 2.58 ± 0.81c 2.38 ± 0.69a 2.14 ± 0.58c 2.44 ± 0.59d 2.57 ± 0.65e 0.001 <0.001
Sitosterol/TC 1.42 ± 0.50 1.28 ± 0.45a 1.16 ± 0.38c 1.04 ± 0.34c 1.17 ± 0.36d 1.28 ± 0.39d 0.004* <0.001*
Avenasterol/TC 0.49 ± 0.13 0.44 ± 0.12f 0.45 ± 0.11 0.42 ± 0.07f 0.44 ± 0.10 0.44 ± 0.12 0.013 0.336
Campestanol/TC 0.02 ± 0.08 0.04 ± 0.02f 0.07 ± 0.03c 0.07 ± 0.02c 0.05 ± 0.02b 0.03 ± 0.09d <0.001 <0.001
Sitostanol/TC 0.08 ± 0.04 0.13 ± 0.07a 0.16 ± 0.05c 0.18 ± 0.04c 0.15 ± 0.04e 0.12 ± 0.04d <0.001 <0.001
Cholestanol/TC 1.32 ± 0.26 1.30 ± 0.27 1.39 ± 0.24 1.30 ± 0.23 1.32 ± 0.28 1.31 ± 0.28 0.185 0.517
  1. Values are means ± SD, n = 11. TC = total cholesterol 1 indicates the significance of the differences for overall changes during the experimental period (days 0–15) 2 indicates the significance of the differences for overall changes during the follow-up period (days 15–22) analyzed with analysis of variance for repeated measurements (MANOVA) or Friedman Two-way ANOVA test (Avenasterol/TC). * Initial concentration (0 day or 15 days) was significantly different by ANOVA between the two starting batches; therefore, the initial concentration was taken into account in the analyses as a covariate. a P < 0.01, c P < 0.001, f P < 0.05 significantly different from the values of 0 day analyzed with paired t-test or Wilcoxon matched-paired test with Bonferroni correction. b P < 0.05, d P < 0.001, e P < 0.01 significantly different from the values of 15 days analyzed with paired t-test with Bonferroni correction.