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Table 3 Ratios of serum cholesterol precursors and plant sterols to total cholesterol (10-2mg/mg of cholesterol) during the study.

From: Short-term LDL cholesterol-lowering efficacy of plant stanol esters

 

Experimental period

Follow-up period

  
 

0 day

4 days

8 days

15 days

17 or 18 days

22 days

P1

P2

Squalene/TC

0.49 ± 0.12

0.46 ± 0.14

0.55 ± 0.20

0.51± 0.12

0.46 ± 0.14

0.48 ± 0.20

0.390

0.662

Δ8-cholestenol/TC

0.22 ± 0.09

0.22 ± 0.09

0.24 ± 0.06

0.25 ± 0.08

0.24 ± 0.07

0.23 ± 0.07

0.101

0.280

Δ7-lathosterol/TC

1.67 ± 0.58

1.75 ± 0.60

1.89 ± 0.34

1.98 ± 0.48a

1.86 ± 0.46

1.71 ± 0.45

0.012

0.116

Desmosterol/TC

1.05 ± 0.26

1.01 ± 0.18

1.09 ± 0.15

1.13 ± 0.14

1.04 ± 0.15b

1.06 ± 0.13

0.026

0.018

Campesterol/TC

2.86 ± 0.89

2.58 ± 0.81c

2.38 ± 0.69a

2.14 ± 0.58c

2.44 ± 0.59d

2.57 ± 0.65e

0.001

<0.001

Sitosterol/TC

1.42 ± 0.50

1.28 ± 0.45a

1.16 ± 0.38c

1.04 ± 0.34c

1.17 ± 0.36d

1.28 ± 0.39d

0.004*

<0.001*

Avenasterol/TC

0.49 ± 0.13

0.44 ± 0.12f

0.45 ± 0.11

0.42 ± 0.07f

0.44 ± 0.10

0.44 ± 0.12

0.013

0.336

Campestanol/TC

0.02 ± 0.08

0.04 ± 0.02f

0.07 ± 0.03c

0.07 ± 0.02c

0.05 ± 0.02b

0.03 ± 0.09d

<0.001

<0.001

Sitostanol/TC

0.08 ± 0.04

0.13 ± 0.07a

0.16 ± 0.05c

0.18 ± 0.04c

0.15 ± 0.04e

0.12 ± 0.04d

<0.001

<0.001

Cholestanol/TC

1.32 ± 0.26

1.30 ± 0.27

1.39 ± 0.24

1.30 ± 0.23

1.32 ± 0.28

1.31 ± 0.28

0.185

0.517

  1. Values are means ± SD, n = 11. TC = total cholesterol 1 indicates the significance of the differences for overall changes during the experimental period (days 0–15) 2 indicates the significance of the differences for overall changes during the follow-up period (days 15–22) analyzed with analysis of variance for repeated measurements (MANOVA) or Friedman Two-way ANOVA test (Avenasterol/TC). * Initial concentration (0 day or 15 days) was significantly different by ANOVA between the two starting batches; therefore, the initial concentration was taken into account in the analyses as a covariate. a P < 0.01, c P < 0.001, f P < 0.05 significantly different from the values of 0 day analyzed with paired t-test or Wilcoxon matched-paired test with Bonferroni correction. b P < 0.05, d P < 0.001, e P < 0.01 significantly different from the values of 15 days analyzed with paired t-test with Bonferroni correction.