Cardiac abnormalities in patients with mitochondrial DNA mutation 3243A>G

Table 1 Comparison of the patients with the 3243A> G mutation and the matched controls.

	Patients with 3243A>G	Controls	p-value
Gender (% men)	38.5	38.5	1.00
Age (yrs)	46.7 ± 12.7	46.8 ± 11.5	0.63
Hypertension (n)	10	10	1.00
Diabetes mellitus (n)	20	7	0.001
Left ventricular dimensions
ST(D) (mm)	12.2 ± 3.2	10.0 ± 1.7	0.003
PWT(D) (mm)	12.1 ± 3.7	10.0 ± 1.8	0.02
LVD(D) (mm)	43.4 ± 5.8	49.6 ± 5.4	<0.001
LVH^* (n)	19	6	0.002
Left ventricular mass
LVMI (g/m²)	127 ± 54	102 ± 24	0.06
LVH^† (n)	12	3	0.02

ST(D), thickness of interventricular septum in diastole; PWT(D), thickness of posterior ventricular wall in diastole; LVD(D), left ventricular end-diastolic diameter; LVH^*, left ventricular hypertrophy = septal or posterior wall end-diastolic thickness ≥ 12 mm in non-hypertensives and ≥ 14 mm in medically treated hypertensives [23]; LVMI, left ventricular mass/body surface area, where LVM is left ventricular mass calculated by the method of American Society of Echocardiography: 0.8 × (1.04 × ((LVID/10 + IVS/10 + PVW/10)³ – (LVID/10)³) + 0.6 [24, 25]; LVH^†, left ventricular hypertrophy = LVMI over 134 g/m² for men and 110 g/m² for women [25]. Values are means ± standard deviations.

ISSN: 1471-2261