Table 3 Results of meta-analysis in each group and mean CAP volume in each group at baseline and follow up in Western and Asian
Group | Included arms (case) | CAP volume at baseline (mm3) | CAP volume at follow up (mm3) | Pooled SMD (95% CI,p) | Heterogeneity test | Sensitivity analyses | Egger’s test | |||
|---|---|---|---|---|---|---|---|---|---|---|
χ2test (p) | I 2 | Lower SMD (95% CI) | Upper SMD (95% CI) | |||||||
Western | <70 mg | 3(905) | 171.4 ± 32.7 | 160.6 ± 29.7 | −0.156(−0.248 ~ −0.064, 0.001) | 0.33(0.886) | 0 | −0.139 (−0.257 ~ −0.021) Without 2006 ASTEROID Ros | −0.175 (−0.317 ~ −0.034) Without 2011 SATURN Ros | 0.789 |
>70 ≤ 100 HPmg | 3(812) | 151.9 ± 30.4 | 147.9 ± 31.9 | −0.065(−0.136 ~ 0.032, 0.189) | 0.71(0.699) | 0 |  |  | 0.987 | |
>70 ≤ 100 MPmg | 5(1548) | 195.8 ± 2.3 | 191.8 ± 4.7 | −0.045(−0.115 ~ −0.026, 0.215) | 1.59(0.811) | 0 |  |  | 0.500 | |
>70 ≤ 100 LPmg | 6(1061) | 201.2 ± 15.1 | 197.3 ± 15.0 | −0.045(−0.130 ~ 0.040, 0.301) | 1.14(0.950) | 0 |  |  | 0.241 | |
>100 mg | 3(464) | 197.6 ± 3.5 | 201.1 ± 1.9 | 0.034(−0.094 ~ 0.163, 0.601) | 0.03(0.984) | 0 |  |  |  | |
>50% | 1(349) | 212.2 ± 81.3 | 197.5 ± 79.1 | −0.183(−0.332 ~ −0.035, 0.016) |  |  |  |  |  | |
>40 ≤ 50% | 4(1332) | 148.8 ± 24.0 | 143.1 ± 25.6 | −0.095(−0.171 ~ −0.019, 0.014) | 1.64(0.651) | 0 | −0.065 (−0.163 ~ 0.032) Without 2011 SATURN Ros | −0.116 (−0.201 ~ −0.032) Without 2004 REVERSAL Ato | 0.804 | |
>30 ≤ 40% | 1(36) | 169.1 ± 77.3 | 161.5 ± 75.2 | −0.099(−0.561 ~ 0.363, 0.675) | 0.00(0.000) | 0 |  |  |  | |
>0 ≤ 30% | 6(1797) | 195.6 ± 2.1 | 192.9 ± 5.1 | −0.032(−0.098 ~ 0.033, 0.335) | 2.45(0.784) | 0 |  |  |  | |
<0% | 8(1276) | 201.2 ± 13.8 | 198.3 ± 13.8 | −0.034(−0.111 ~ 0.044, 0.396) | 1.55(0.981) | 0 |  |  | 0.087 | |
Asian | <70 mg | 4(345) | 192.2 ± 59.9 | 179.9 ± 53.0 | −0.157(−0.307 ~ −0.008, 0.039) | 0.24(0.955) | 0 | −0.126 (−0.314 ~ 0.063) Without 2012 ARTMAP Ros | −0.187 (−0.383 ~ 0.008) Without 2012 ARTMAP Ato | 0.970 |
>70 ≤ 100 HPmg | 8(540) | 96.4 ± 99.3 | 87.5 ± 92.0 | −0.211(−0.331 ~ −0.092, 0.001) | 2.68(0.913) | 0 | −0.177 (−0.314 ~ −0.040) Without 2009 JAPAN-ACS Ato | −0.231(−0.368 ~ −0.094) Without 2009 COSMOS Ros | 0.083 | |
>100 mg | 8(235) | 133.0 ± 139.6 | 134.3 ± 143.8 | −0.029(−0.210 ~ 0.152, 0.750) | 2.14(0.952) | 0 |  |  |  | |
>40 ≤ 50% | 4(345) | 192.2 ± 56.9 | 179.9 ± 53.0 | −0.157(−0.307 ~ −0.008, 0.039) | 0.33(0.955) | 0 | −0.126 (−0.314 ~ 0.063) Without 2012 ARTMAP Ros | −0.187 (−0.383 ~ 0.008) Without 2012 ARTMAP Ato | 0.970 | |
>30 ≤ 40% | 9(558) | 98.6 ± 98.5 | 90.0 ± 91.6 | −0.206(−0.324 ~ −0.088, 0.001) | 2.91(0.840) | 0 | −0.172 (−0.306 ~ −0.038) Without 2009 JAPAN-ACS Ato | −0.223 (−0.357 ~ −0.089) Without 2009 COSMOS Ros | 0.004 | |
>0 ≤ 30% | 7(217) | 130.2 ± 144.9 | 131.8 ± 149.4 | −0.028(−0.216 ~ 0.161, 0.773) | 2.14(0.907) | 0 |  |  |  | |