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Table 3 Results of meta-analysis in each group and mean CAP volume in each group at baseline and follow up in Western and Asian

From: The difference between Asian and Western in the effect of LDL-C lowering therapy on coronary atherosclerotic plaque: a meta-analysis report

Group Included arms (case) CAP volume at baseline (mm3) CAP volume at follow up (mm3) Pooled SMD (95% CI,p) Heterogeneity test Sensitivity analyses Egger’s test
χ2test (p) I 2 Lower SMD (95% CI) Upper SMD (95% CI)
Western <70 mg 3(905) 171.4 ± 32.7 160.6 ± 29.7 −0.156(−0.248 ~ −0.064, 0.001) 0.33(0.886) 0 −0.139 (−0.257 ~ −0.021) Without 2006 ASTEROID Ros −0.175 (−0.317 ~ −0.034) Without 2011 SATURN Ros 0.789
>70 ≤ 100 HPmg 3(812) 151.9 ± 30.4 147.9 ± 31.9 −0.065(−0.136 ~ 0.032, 0.189) 0.71(0.699) 0    0.987
>70 ≤ 100 MPmg 5(1548) 195.8 ± 2.3 191.8 ± 4.7 −0.045(−0.115 ~ −0.026, 0.215) 1.59(0.811) 0    0.500
>70 ≤ 100 LPmg 6(1061) 201.2 ± 15.1 197.3 ± 15.0 −0.045(−0.130 ~ 0.040, 0.301) 1.14(0.950) 0    0.241
>100 mg 3(464) 197.6 ± 3.5 201.1 ± 1.9 0.034(−0.094 ~ 0.163, 0.601) 0.03(0.984) 0    
>50% 1(349) 212.2 ± 81.3 197.5 ± 79.1 −0.183(−0.332 ~ −0.035, 0.016)      
>40 ≤ 50% 4(1332) 148.8 ± 24.0 143.1 ± 25.6 −0.095(−0.171 ~ −0.019, 0.014) 1.64(0.651) 0 −0.065 (−0.163 ~ 0.032) Without 2011 SATURN Ros −0.116 (−0.201 ~ −0.032) Without 2004 REVERSAL Ato 0.804
>30 ≤ 40% 1(36) 169.1 ± 77.3 161.5 ± 75.2 −0.099(−0.561 ~ 0.363, 0.675) 0.00(0.000) 0    
>0 ≤ 30% 6(1797) 195.6 ± 2.1 192.9 ± 5.1 −0.032(−0.098 ~ 0.033, 0.335) 2.45(0.784) 0    
<0% 8(1276) 201.2 ± 13.8 198.3 ± 13.8 −0.034(−0.111 ~ 0.044, 0.396) 1.55(0.981) 0    0.087
Asian <70 mg 4(345) 192.2 ± 59.9 179.9 ± 53.0 −0.157(−0.307 ~ −0.008, 0.039) 0.24(0.955) 0 −0.126 (−0.314 ~ 0.063) Without 2012 ARTMAP Ros −0.187 (−0.383 ~ 0.008) Without 2012 ARTMAP Ato 0.970
>70 ≤ 100 HPmg 8(540) 96.4 ± 99.3 87.5 ± 92.0 −0.211(−0.331 ~ −0.092, 0.001) 2.68(0.913) 0 −0.177 (−0.314 ~ −0.040) Without 2009 JAPAN-ACS Ato −0.231(−0.368 ~ −0.094) Without 2009 COSMOS Ros 0.083
>100 mg 8(235) 133.0 ± 139.6 134.3 ± 143.8 −0.029(−0.210 ~ 0.152, 0.750) 2.14(0.952) 0    
>40 ≤ 50% 4(345) 192.2 ± 56.9 179.9 ± 53.0 −0.157(−0.307 ~ −0.008, 0.039) 0.33(0.955) 0 −0.126 (−0.314 ~ 0.063) Without 2012 ARTMAP Ros −0.187 (−0.383 ~ 0.008) Without 2012 ARTMAP Ato 0.970
>30 ≤ 40% 9(558) 98.6 ± 98.5 90.0 ± 91.6 −0.206(−0.324 ~ −0.088, 0.001) 2.91(0.840) 0 −0.172 (−0.306 ~ −0.038) Without 2009 JAPAN-ACS Ato −0.223 (−0.357 ~ −0.089) Without 2009 COSMOS Ros 0.004
>0 ≤ 30% 7(217) 130.2 ± 144.9 131.8 ± 149.4 −0.028(−0.216 ~ 0.161, 0.773) 2.14(0.907) 0    
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