ACTN3R577X polymorphism and long-term survival in patients with chronic heart failure

Table 1 Baseline demographic, biochemical, echocardiographic, and clinical characteristics according to ACTN3 R577X polymorphism of the patients with heart failure

	RR (n = 178)	RX + XX (n = 285)	p value
Gender (male), %	64.6	58.9	0.22
Age, years	57 ± 14	58 ± 14	0.27
Body mass index, kg/m ²	26 ± 5	25 ± 5	0.23
Ethnicity (Whites), %	68.5	78.2	0.09
Heart failure etiology, %
Chagasic	9.6	11.9
Idiopathic	9.6	10.5
Hypertensive	35.4	24.9	0.29
Ischemic	25.3	30.9
Valve disease	14.5	15.8
Other	5.6	6.0
Hypertension, %	62.4	62.8	0.92
Diabetes, %	25.3	25.6	0.93
Current smoker, %	12.4	7.0	0.06
Total cholesterol, mg/dL	193 ± 49	190 ± 52	0.57
LDL-C, mg/dL	123 ± 38	119 ± 44	0.34
HDL-C, mg/dL	46 ± 15	45 ± 15	0.69
Triglycerides, mg/dL	121 ± 68	123 ± 6.6	0.75
Glycemia, mg/dL	115 ± 38	109 ± 49	0.27
Creatinine, mg/dL	1.4 ± 0.8	1.4 ± 0.7	0.92
Frequency of death, %	46.6	54.7	0.08
Systolic blood pressure, mmHg	123 ± 33	121 ± 30	0.48
Diastolic blood pressure, mmHg	78 ± 20	75 ± 17	0.15
Heart rate, ppm	80 ± 14	79 ± 12	0.31
LVEF, %	46 ± 18	45 ± 19	0.71
LVM, g	259 ± 98	245 ± 83	0.12
LVEDD, mm	62 ± 12	62 ± 11	0.97
LVESD, mm	49 ± 15	49 ± 14	0.77

LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; LVEF: Left ventricular ejection fraction; LVM: Left ventricular mass; LVEDD: Left ventricular end-diastolic diameter; LVESD: Left ventricular end-systolic diameter.

ISSN: 1471-2261