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Table 2 Echocardiographic and blood pressure analysis of WT and ae3 −/− mice

From: Resistance to cardiomyocyte hypertrophy in ae3 −/− mice, deficient in the AE3 Cl/HCO3 exchanger

Parameter

WT

ae3 −/−

Ejection fraction, %

65 ± 3

67 ± 7

Fractional shortening, %

35 ± 3

37 ± 7

IVSd, mm

0.70 ± 0.01

0.75 ± 0.04

LVIDd, mm

3.5 ± 0.1

3.4 ± 0.1

LVPWd, mm

0.67 ± 0.03

0.70 ± 0.03

IVSs, mm

1.08 ± 0.03

1.11 ± 0.09

LVIDs, mm

2.3 ± 0.1

2.1 ± 0.3

LVPWs, mm

1.05 ± 0.07

1.05 ± 0.12

MV E Velocity, mm.s−1

730 ± 50

710 ± 50

MV A Velocity, mm.s−1

390 ± 30

520 ± 40

MV E/A ratio

1.9 ± 0.1

1.4 ± 0.1

E/E’

24 ± 3

21 ± 4

IVRT, ms

16 ± 0

17 ± 2

TEI index

0.63 ± 0.03

0.61 ± 0.02

Systolic pressure, mm Hg

102 ± 7

100 ± 9

Diastolic pressure, mm Hg

66 ± 6

64 ± 8

Flow, ml.min−1

11 ± 1

10 ± 1

Volume of blood, ml

36 ± 6

31 ± 5

Heart rate, beats.min−1

699 ± 1

721 ± 49

  1. All experiments were performed on male mice. Values are expressed as means ± S.E.M. (n = 3 per group for echocardiography; n = 7 for tail cuff parameters, with three replicates over three separate days (bottom five rows of the table)); P < 0.05. IVSd, diastolic intraventricular septal wall thickness; LVIDd, diastolic left ventricular internal diameter; LVPWd, diastolic left ventricular posterior wall thickness; IVSs, systolic intraventricular septal wall thickness; LVIDs, systolic left ventricular internal diameter; LVPWs, systolic left ventricular posterior wall thickness; MV E velocity, peak E wave mitral valve velocity; MV A velocity, peak A wave mitral valve velocity; MV E/A, ratio of peak E wave mitral valve velocity to peak A wave mitral valve velocity; E/E’, ratio of peak E wave mitral valve velocity to E wave mitral valve tissue motion; IVRT, isovolumic relaxation time.