Table 5 Incident rates and median time for T2DM diagnosis at different follow-up times, according to hypertension and CVD diagnosis
| Â | Â | Statin use | |||
|---|---|---|---|---|---|
| Â | Â | Yes | No | ||
Follow up time (years) PS [5-95%] (N = 1,448,993) | Hazard ratio (95% CI)* | Incident T2DM per 1000 person-years (95% CI) | Nº T2DM /Median time (days) | Incident T2DM per 1000 person-years (95% CI) | Nº T2DM /Median time (days) |
Total sample | |||||
0-1Â yr | 1.52 (1.47-1.57) | 19.97 (19.52-20.42) | 7,634/139 | 11.53 (11.33-11.74) | 12,189/210 |
1-3Â yr | 1.22 (1.19-1.25) | 20.11 (19.78-20.44) | 13,786/727 | 13.35 (13.34-13.37) | 21,418/644 |
3-5Â yr | 1.73 (1.68-1.80) | 24.56 (24.12-25.00) | 11,858/1,440 | 11.61 (11.38-11.84) | 9,773/1,394 |
5-10Â yr | 2.25 (2.17-2.34) | 30.03 (29.55-30.53) | 14,523/2,450 | 10.85 (10.59-11.12) | 6,534/2,312 |
10-15Â yr | 3.05 (2.71-3.43) | 34.93 (33.53-36.39) | 2,292/4,174 | 10.20 (9.38-11.10) | 543/4,166 |
15-20Â yr | 3.63 (2.44-5.38) | 42.24 (36.90-48.36) | 210/5,877 | 12.24 (9.10-16.51) | 43/5,773 |
20-25Â yr | n.e. | 13.10 (1.84-93.00) | 1/ - | 0 | 0/ - |
No hypertension | |||||
0-1Â yr | 2.05 (1.96-2.15) | 19.53 (18.97-20.11) | 4,486/134 | 8.65 (8.44-8.85) | 6,893/215 |
1-3Â yr | 1.50 (1.45-1.55) | 18.64 (18.23-19.06) | 7,694/727 | 10.60 (10.42-10.77) | 13,114/653 |
3-5Â yr | 2.00 (1.92-2.09) | 22.15 (21.61-22.69) | 6,463/1,439 | 9.56 (9.33-9.80) | 6,550/1,400 |
5-10Â yr | 2.50 (2.39-2.61) | 27.65 (27.06-28.24) | 8,502/2,482 | 9.32 (9.06-9.59) | 4,750/2,335 |
10-15Â yr | 3.14 (2.75-3.58) | 32.86 (31.26-34.55) | 1,541/4,180 | 9.31 (8.48-10.21) | 446/4,186 |
15-20Â yr | 3.84 (2.52-5.86) | 41.61 (35.64-48.59) | 160/5,877 | 11.55 (8.41-15.88) | 38/5,780 |
20-25Â yr | n.e. | 0 | 0/ - | 0 | 0/ - |
Hypertension | |||||
0-1Â yr | 0.96 (0.91-1.01) | 20.62 (19.91-21.35) | 3,148/145 | 20.40 (19.86-20.96) | 5,296/204 |
1-3Â yr | 0.84 (0.81-0.88) | 22.33 (21.77-22.89) | 6,092/726 | 24.20 (23.68-24.72) | 8,304/625 |
3-5Â yr | 1.22 (1.15-1.29) | 28.24 (27.50-29.00) | 5,395/1,442 | 20.51 (19.82-21.23) | 3,223/1,380 |
5-10Â yr | 1.56 (1.46-1.67) | 34.22 (33.37-35.10) | 6,021/2,405 | 19.25 (18.38-20.17) | 1,784/2,264 |
10-15Â yr | 2.19 (1.68-2.84) | 40.09 (37.32-43.06) | 751/4,156 | 18.33 (15.02-22.37) | 97/4,073 |
15-20Â yr | 2.32 (0.77-7.01) | 44.38 (33.64-58.56) | 50/5,876 | 22.38 (9.31-53.77) | 5/ - |
20-25Â yr | n.e. | 0 | 0/ - | 0 | 0/ - |
No CVD | |||||
0-1Â yr | 1.74 (1.67-1.80) | 20.72 (20.22-21.24) | 6,260/136 | 10.74 (10.54-10.95) | 10,474/213 |
1-3Â yr | 1.31 (1.28-1.35) | 20.37 (19.99-20.75) | 11,037/725 | 12.93 (12.75-13.11) | 19,254/647 |
3-5Â yr | 1.85 (1.78-1.92) | 24.94 (24.44-25.45) | 9,325/1,438 | 11.18 (10.95-11.42) | 9,022/1,393 |
5-10Â yr | 2.34 (2.24-2.43) | 30.44 (29.86-31.02) | 10,512/2,416 | 10.56 (10.30-10.83) | 6,134/2,317 |
10-15Â yr | 2.96 (2.61-3.35) | 33.58 (31.85-35.97) | 1,379/4,151 | 10.08 (9.26-10.99) | 523/4,166 |
15-20Â yr | 3.76 (2.49-5.67) | 41.78 (35.54-49.11) | 147/5,985 | 11.81 (8.70-16.04) | 41/5,773 |
20-25Â yr | n.e. | 0 | 0/ - | 0 | 0/ - |
CVD | |||||
0-1Â yr | 0.75 (0.69-0.82) | 17.11 (16.23-18.04) | 1,374/147 | 21.05 (20.08-22.07) | 1,715/196 |
1-3Â yr | 0.75 (0.70-0.80) | 19.12 (18.42-19.85) | 2,749/733 | 23.77 (22.79-24.79) | 2,164/613 |
3-5Â yr | 0.97 (0.88-1.06) | 23.24 (22.35-24.17) | 2,533/1,445 | 21.30 (19.83-22.88) | 751/1,408 |
5-10Â yr | 1.34 (1.19-1.50) | 29.05 (28.16-29.96) | 4,011/2,540 | 18.73 (16.98-20.66) | 400/2,223 |
10-15Â yr | 2.26 (1.42-3.57) | 37.19 (34.85-39.68) | 913/4,224 | 14.70 (9.49-22.79) | 20/4,204 |
15-20Â yr | 1.45 (0.31-6.74) | 43.36 (33.87-55.08) | 63/5,762 | 48.47 (12.12-193.81) | 2/ - |
20-25Â yr | n.e. | 0 | 0/ - | 0 | 0/ - |